Association of NAT2 polymorphisms with susceptibility to psoriasis in the Moscow population
- 25 February 2009
- journal article
- Published by Pleiades Publishing Ltd in Molecular Biology
- Vol. 43 (1), 55-67
- https://doi.org/10.1134/s0026893309010087
Abstract
N-acetyltransferase 2 (NAT2) is a key enzyme of biotransformation phase II that metabolizes genotoxic compounds such as carcinogens and mutagens in different types of cells. A decreased NAT2 activity may correlate with sensitivity to harmful environmental factors, thus increasing susceptibility to different multifactorial diseases, including dermatologic conditions like psoriasis. A biochip developed in our lab to detect 17 NAT2 SNPs was tested on 279 clinical DNA samples from 180 patients with psoriasis and 99 healthy individuals, all residents of Moscow. Six polymorphisms that are most common in European populations (282C > T, 341T > C, 481C > T, 590G > A, 803A > G, and 857G > A) were detected. The NAT2 allele and genotype frequencies for individual SNPs did not differ between patients and healthy individuals. The frequency of the slow acetylation phenotype was increased in patients with type II psoriasis and in normosthenic patients as compared to controls (OR = 1.76, P = 0.177 and OR = 2.07, P = 0.050, respectively). Genotype 341C/C,481T/T,803G/G was significantly more frequent in patients who smoked at least one pack of cigarettes per day and in those who regularly consumed alcohol than in controls (OR = 7.42, P = 0.008 and OR = 106.11, P = 0.003, respectively). The frequency of genotype 341T/T, 481C/C, 590A/-, 803A/A was increased in patients with adverse reactions to medications (OR = 2.05, P = 0.099). Thus, our data suggest that some NAT2 genotypes in combination with certain lifestyles can be considered risk factors of psoriasis in the Moscow population.Keywords
This publication has 24 references indexed in Scilit:
- Polymorphisms in xenobiotic‐metabolizing genes and the risk of chronic lymphocytic leukemia and non‐Hodgkin's lymphoma in adult Russian patientsAmerican Journal of Hematology, 2007
- Association of the diplotype configuration at the N-acetyltransferase 2 gene with adverse events with co-trimoxazole in Japanese patients with systemic lupus erythematosusArthritis Research & Therapy, 2007
- Deciphering the Ancient and Complex Evolutionary History of Human Arylamine N-Acetyltransferase GenesAmerican Journal of Human Genetics, 2006
- Variation of theN-Acetyltransferase 2Gene in a Romanian and a Kyrgyz PopulationCancer Epidemiology, Biomarkers & Prevention, 2006
- Psoriasis: epidemiology, clinical features, and quality of lifeAnnals Of The Rheumatic Diseases, 2005
- N-Acetyltransferase 2 Phenotype May Be Associated with Susceptibility to Age-Related CataractCurrent Eye Research, 2005
- ‘Comparison of extremes’ approach provides evidence against the modifying role of NAT2 polymorphism in lung cancer susceptibilityCancer Letters, 2004
- Generalized Skin Reactions in Relation to Trichloroethylene Exposure: A Review from the Viewpoint of Drug‐Metabolizing EnzymesJournal of Occupational Health, 2003
- N -Acetyltransferase 2 Polymorphism Is Not Related to the Risk of Advanced Alcoholic Liver DiseaseScandinavian Journal of Gastroenterology, 2002
- Preliminary phenotypic map of chromosome 4p16 based on 4p deletionsAmerican Journal of Medical Genetics, 1995