Conversion of Alkyl Halides into Alcohols Using a Near Stoichiometric Amount of Molecular Oxygen: An Efficient Route to 18O- and 17O-Labeled Alcohols

Abstract

In the presence of near stoichiometric amount of molecular oxygen, various alkyl halides were converted to the corresponding alcohols in high yields through aerobic radical reaction promoted by a Bu₂(t-Bu)SnCl/NaBH₃CN catalytic system. Isotope-labeled alcohols were prepared with ¹⁸O₂ and ¹⁷O₂ without loss of the isotopic purities of the starting oxygen gases.