Advances in pancreatic cancer
- 1 September 2011
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in Current Opinion in Gastroenterology
- Vol. 27 (5), 460-466
- https://doi.org/10.1097/mog.0b013e328349e31f
Abstract
This review intends to describe recent studies on the interaction between pancreatic cancer cells and tumor stroma, and potential opportunities and limitations to therapeutically targeting the stroma. Pancreatic cancer is characterized by densely desmoplastic stroma. It is becoming increasingly clear that there are complex and mutually supportive interactions between cancer cells and the stroma. Specific signaling pathways exist between cancer cells and cancer-associated fibroblasts that contribute to hypoxic desmoplasia. Recent developments in therapeutic approaches to targeting the stroma have demonstrated potential for enhancing efficacy of cytotoxic therapies. However, the heterogeneity and genomic complexity between tumors has also become more evident based on recent findings. There is increasing evidence for hierarchy of cancer cells with identification of a subpopulation of cancer stem cells that are inherently resistant to traditional therapies. Targeting pancreatic cancer stroma is a novel therapeutic strategy that appears justified based on recent studies; however, continued focus is needed to develop more effective therapies against cells resistant to standard chemotherapy.Keywords
This publication has 59 references indexed in Scilit:
- Hallmarks of Cancer: The Next GenerationCell, 2011
- Bone Marrow-Derived Myofibroblasts Contribute to the Mesenchymal Stem Cell Niche and Promote Tumor GrowthCancer Cell, 2011
- Distant metastasis occurs late during the genetic evolution of pancreatic cancerNature, 2010
- The patterns and dynamics of genomic instability in metastatic pancreatic cancerNature, 2010
- Tumors as Organs: Complex Tissues that Interface with the Entire OrganismDevelopmental Cell, 2010
- Cancer-Associated Fibroblasts Are Activated in Incipient Neoplasia to Orchestrate Tumor-Promoting Inflammation in an NF-κB-Dependent MannerCancer Cell, 2010
- Carcinoma-associated fibroblasts are a rate-limiting determinant for tumour progressionSeminars in Cell & Developmental Biology, 2009
- Sonic hedgehog paracrine signaling regulates metastasis and lymphangiogenesis in pancreatic cancerOncogene, 2009
- Pancreatic cancer–associated stroma productionThe American Journal of Surgery, 2007
- The Hallmarks of CancerCell, 2000