Phosphorylation of isocitrate dehydrogenase as a demonstration of enhanced sensitivity in covalent regulation
- 1 September 1983
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 305 (5932), 286-290
- https://doi.org/10.1038/305286a0
Abstract
The sensitivity to regulation of proteins undergoing covalent modification can be greatly increased when the substrates saturate the converter enzymes. This phenomenon, termed zero-order ultrasensitivity, occurs in the reversible phosphorylation of [Escherichia coli] isocitrate dehydrogenase. The possibility that this enhanced sensitivity is a common feature of covalent regulatory systems is discussed.This publication has 21 references indexed in Scilit:
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