Mitophagy: mechanisms, pathophysiological roles, and analysis
- 1 July 2012
- journal article
- review article
- Published by Walter de Gruyter GmbH in Biological Chemistry
- Vol. 393 (7), 547-564
- https://doi.org/10.1515/hsz-2012-0119
Abstract
Mitochondria are essential organelles that regulate cellular energy homeostasis and cell death. The removal of damaged mitochondria through autophagy, a process called mitophagy, is thus critical for maintaining proper cellular functions. Indeed, mitophagy has been recently proposed to play critical roles in terminal differentiation of red blood cells, paternal mitochondrial degradation, neurodegenerative diseases, and ischemia or drug-induced tissue injury. Removal of damaged mitochondria through autophagy requires two steps: induction of general autophagy and priming of damaged mitochondria for selective autophagic recognition. Recent progress in mitophagy studies reveals that mitochondrial priming is mediated either by the Pink1-Parkin signaling pathway or the mitophagic receptors Nix and Bnip3. In this review, we summarize our current knowledge on the mechanisms of mitophagy. We also discuss the pathophysiological roles of mitophagy and current assays used to monitor mitophagy.Keywords
This publication has 100 references indexed in Scilit:
- Nix is a selective autophagy receptor for mitochondrial clearanceEMBO Reports, 2009
- Viruses and autophagyReviews in Medical Virology, 2009
- Atg32 Is a Mitochondrial Protein that Confers Selectivity during MitophagyDevelopmental Cell, 2009
- A Role for Ubiquitin in Selective AutophagyMolecular Cell, 2009
- Autophagy regulates lipid metabolismNature, 2009
- Restoration of chaperone-mediated autophagy in aging liver improves cellular maintenance and hepatic functionNature Medicine, 2008
- Essential role for Nix in autophagic maturation of erythroid cellsNature, 2008
- Selective degradation of mitochondria by mitophagyArchives of Biochemistry and Biophysics, 2007
- Loss of autophagy in the central nervous system causes neurodegeneration in miceNature, 2006
- Eating Oneself and Uninvited Guests: Autophagy-Related Pathways in Cellular DefenseCell, 2005