Effects of Atropine and Scopolamine on the Cardiovascular System in Man

Abstract

The cardiovascular effects of atropine and scopolamine were compared in male volunteers. The bases of atropine and scopolamine were found to be equipotent. Scopolamine was faster in onset and shorter in duration of action. Both exerted their principal effect on heart rate; low doses decreased and large doses accelerated heart rate. Cardiac output changed parallel to the changes of heart rate. Stroke volume was not affected. Both atropine and scopolamine were equally effective in enhancing the action of mephentermine on heart rate and blood pressure.