Responses of Saccharomyces cerevisiae to nitrogen starvation in wine alcoholic fermentation
- 23 July 2015
- journal article
- review article
- Published by Springer Science and Business Media LLC in Applied Microbiology and Biotechnology
- Vol. 99 (17), 7025-7034
- https://doi.org/10.1007/s00253-015-6810-z
Abstract
Nitrogen is an important nutrient in alcoholic fermentation because its starvation affects both fermentation kinetics and the formation of yeast metabolites. In most alcoholic fermentations, yeasts have to ferment in nitrogen-starved conditions, which requires modifications of cell functions to maintain a high sugar flux and enable cell survival for long periods in stressful conditions. In this review, we present an overview of our current understanding of the responses of the wine yeast Saccharomyces cerevisiae to variations of nitrogen availability. Adaptation to nitrogen starvation involves changes in the activity of signaling pathways such as target of rapamycin (TOR) and nitrogen catabolite repression (NCR), which are important for the remodeling of gene expression and the establishment of stress responses. Upon starvation, protein degradation pathways involving autophagy and the proteasome play a major role in nitrogen recycling and the adjustment of cellular activity. Recent progress in the understanding of the role of these mechanisms should enable advances in fermentation management and the design of novel targets for the selection or improvement of yeast strains.Keywords
This publication has 88 references indexed in Scilit:
- Impact of Nutrient Imbalance on Wine Alcoholic Fermentations: Nitrogen Excess Enhances Yeast Cell Death in Lipid-Limited MustPLOS ONE, 2013
- Sequential Use of Nitrogen Compounds by Saccharomyces cerevisiae during Wine Fermentation: a Model Based on Kinetic and Regulation Characteristics of Nitrogen PermeasesApplied and Environmental Microbiology, 2012
- Mapping the interaction of Snf1 with TORC1 in Saccharomyces cerevisiaeMolecular Systems Biology, 2011
- The Tor and PKA signaling pathways independently target the Atg1/Atg13 protein kinase complex to control autophagyProceedings of the National Academy of Sciences of the United States of America, 2009
- Widespread reorganization of metabolic enzymes into reversible assemblies upon nutrient starvationProceedings of the National Academy of Sciences of the United States of America, 2009
- A Chemical Genomics Study Identifies Snf1 as a Repressor of GCN4 TranslationJournal of Biological Chemistry, 2008
- Effect of Nutrient Starvation on the Cellular Composition and Metabolic Capacity of Saccharomyces cerevisiaeApplied and Environmental Microbiology, 2007
- Transcriptional Response ofSaccharomyces cerevisiaeto Different Nitrogen Concentrations during Alcoholic FermentationApplied and Environmental Microbiology, 2007
- Nitrogen Availability and TOR Regulate the Snf1 Protein Kinase in Saccharomyces cerevisiaeEukaryotic Cell, 2006
- Induction of Autophagy by Second-Fermentation Yeasts during Elaboration of Sparkling WinesApplied and Environmental Microbiology, 2006