Elevation of Tissue PO2 with Improvement of Tissue Perfusion by Topically Applied CO2

Abstract
Exposure of skin to CO2 causes local hyperaemia and increases the number and diameter of functioning cutaneous capillaries (Stein and Weinstein, 1942; Kowarschik, 1948; Disi, 1958; Witzleb, 1962). Lipid-soluble CO2 is absorbable into the body through the skin, so that the dissolved CO2 acts as a vasodilator of dermal capillaries (McClellan, 1963).

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