Acute Hepatitis Induced by Chinese Hepatoprotective Herb, Xiao-Chai-Hu-Tang
- 1 February 2006
- journal article
- case report
- Published by Ovid Technologies (Wolters Kluwer Health) in Journal of the Chinese Medical Association
- Vol. 69 (2), 86-88
- https://doi.org/10.1016/s1726-4901(09)70119-4
Abstract
Xiao-chai-hu-tang (syo-saiko-to in Japanese) is a herbal remedy that has been widely used in China for treatment of respiratory, hepatobiliary, and gastrointestinal diseases, particularly among patients with chronic liver disease. However, its safety has recently been challenged. We, herein, report a Chinese patient with acute hepatitis induced by this herb. A 52-year-old woman presented with weakness, fatigue, and tea-colored urine after continual consumption of the decoction of xiao-chai-hu-tang for 1.5 months. Laboratory studies disclosed acute hepatitis even though all of the viral hepatitis markers were negative. Liver biopsy also revealed a picture of acute hepatocellular hepatitis. The symptoms improved after discontinuing the drug, and liver biochemical tests normalized 2 months later. The case report reminds us of the probable adverse drug reaction of herbs, even in some that are claimed to have hepatoprotective effects.Keywords
This publication has 12 references indexed in Scilit:
- When is a herb a drug?European Journal of Gastroenterology & Hepatology, 2005
- Phytochemical and biological analysis of Skullcap (Scutellaria lateriflora L.): A medicinal plant with anxiolytic propertiesPhytomedicine, 2003
- Pneumonitis Induced by Ou-gon (Scullcap).Internal Medicine, 2001
- Cytochrome P450–generated reactive metabolites cause mitochondrial permeability transition, caspase activation, and apoptosis in rat hepatocytesHepatology, 2000
- Discrimination among Three Species of Medicinal Scutellaria Plants using RAPD MarkersPlanta Medica, 2000
- Sho‐saiko‐to: Japanese herbal medicine for protection against hepatic fibrosis and carcinomaJournal of Gastroenterology and Hepatology, 2000
- Hepatotoxicity of herbal remediesJournal of Hepatology, 1997
- Pneumonitis during interferon and/or herbal drug therapy in patients with chronic active hepatitisEuropean Respiratory Journal, 1996
- Liver injuries induced by herbal medicine, Syo-saiko-to (xiao-chai-hu-tang)Digestive Diseases and Sciences, 1995
- Hepatotoxicity of herbal remedies.BMJ, 1989