Complement-Dependent Transport of Antigen into B Cell Follicles
- 1 September 2010
- journal article
- review article
- Published by The American Association of Immunologists in The Journal of Immunology
- Vol. 185 (5), 2659-2664
- https://doi.org/10.4049/jimmunol.1000522
Abstract
Since the original proposal by Fearon and Locksley (Fearon and Locksley. 1996. Science 272: 50–53) that the complement system linked innate and adaptive immunity, there has been a rapid expansion of studies on this topic. With the advance of intravital imaging, a number of recent papers revealed an additional novel pathway in which complement C3 and its receptors enhance humoral immunity through delivery of Ag to the B cell compartment. In this review, we discuss this pathway and highlight several novel exceptions recently found with a model influenza vaccine, such as mannose-binding lectin opsonization of influenza and uptake by macrophages, and the capture of virus by dendritic cells residing in the medullary compartment of peripheral lymph nodes.Keywords
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