A Model for Transposition of the Colistin Resistance Gene mcr-1 by IS Apl1
- 1 November 2016
- journal article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 60 (11), 6973-6976
- https://doi.org/10.1128/aac.01457-16
Abstract
Analysis of mcr-1 -containing sequences identified a common ∼2,607-bp DNA segment that in many cases is flanked on one or both ends by IS Apl1 . We present evidence that mcr-1 is mobilized by an IS Apl1 composite transposon which has, in some cases, subsequently lost one or both copies of IS Apl1 . We also show that mcr-1 can be mobilized in some circumstances by a single upstream copy of IS Apl1 in conjunction with the remnants of a downstream IS Apl1 .Keywords
Funding Information
- HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases
This publication has 12 references indexed in Scilit:
- Draft Genome Sequence of Escherichia coli S51, a Chicken Isolate Harboring a Chromosomally Encoded mcr-1 GeneMicrobiology Resource Announcements, 2016
- Genetic Features of MCR-1-Producing Colistin-Resistant Escherichia coli Isolates in South AfricaAntimicrobial Agents and Chemotherapy, 2016
- Transferable resistance to colistin: a new but old threat: Table 1.Journal of Antimicrobial Chemotherapy, 2016
- Agents of Last ResortInfectious Disease Clinics of North America, 2016
- Early emergence of mcr-1 in Escherichia coli from food-producing animalsThe Lancet Infectious Diseases, 2016
- Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: a microbiological and molecular biological studyThe Lancet Infectious Diseases, 2015
- ISApl1, a novel insertion element of Actinobacillus pleuropneumoniae, prevents ApxIV-based serological detection of serotype 7 strain AP76Veterinary Microbiology, 2008
- Sub-terminal Sequences Modulating IS30 Transposition in Vivo and in VitroJournal of Molecular Biology, 2008
- Transposition and target specificity of the typical IS30 family element IS1655 from Neisseria meningitidisMolecular Microbiology, 2007
- Importance of Illegitimate Recombination and Transposition in IS30-Associated Excision EventsPlasmid, 1999