IN VITRO FERTILIZATION IS ASSOCIATED WITH AN INCREASED RISK OF HYPOSPADIAS
- 1 June 1999
- journal article
- Published by Ovid Technologies (Wolters Kluwer Health) in Journal of Urology
- Vol. 161 (6), 1954-1957
- https://doi.org/10.1016/s0022-5347(05)68863-5
Abstract
Conclusions Male newborns conceived by IVF have a 5-fold increased risk of hypospadias, which may be related to maternal progesterone administration, or other maternal or fetal endocrine abnormalities that may or may not be related to infertility. Health care providers should be aware of this risk so that they can properly counsel infertile couples seeking assisted reproduction by IVF technology.Keywords
This publication has 22 references indexed in Scilit:
- Fetal Death in Mice Lacking 5 -Reductase Type 1 Caused by Estrogen ExcessMolecular Endocrinology, 1997
- Androgen Receptor Gene Mutations are Rarely Associated with Isolated Penile HypospadiasJournal of Urology, 1996
- 5 alpha-reduced androgens play a key role in murine parturitionMolecular Endocrinology, 1996
- Congenital malformations and psychosocial development in children conceived by in vitro fertilizationThe Journal of Pediatrics, 1989
- Aetiological factors in hypospadias.Journal of Medical Genetics, 1986
- A Joint International Study on the Epidemiology of HypospadiasActa Paediatrica, 1986
- The effect of five synthetic progestational compounds on 5α-reductase activity in genital skin fibroblast monolayersSteroids, 1984
- Progestins during pregnancy and hypospadiasTeratology, 1981
- Maternal Progestins as a Possible Cause of HypospadiasNew England Journal of Medicine, 1979
- INDUCED GENITAL ANOMALIES*Annals of the New York Academy of Sciences, 1967