Imbalance of the CD4+ Subpopulations Expressing CD45RA and CD29 Antigens in the Peripheral Blood of Adults and Children with Down Syndrome
- 1 October 1993
- journal article
- Published by Wiley in Scandinavian Journal of Immunology
- Vol. 38 (4), 323-326
- https://doi.org/10.1111/j.1365-3083.1993.tb01733.x
Abstract
Peripheral blood lymphoid subsets expressing either CD45RA or CD29 antigens, were quantified in 30 children and 59 adults with Down Syndrome and appropriate age-matched controls, by dual immunofluorescence and flow cytometry. Down's patients, both adults and children, displayed a significant decrease of CD4+CD45RA+ cells in comparison with the observed in their age-matched controls, but no difference was found in the CD4+CD29+ subset. These results show clearly the imbalance of these subpopulations in the peripheral blood of individuals with Down syndrome that result in the inversion of the CD45RA/CD29 ratio, due to a major reduction of the CD45RA subset. No obvious difference was found in the CD45RA/CD29 ratio within the CD4 negative cells. Abnormalities of these subpopulations could be indicative of early senescence of the immune system, since age-related changes in Down's persons were in parallel with those observed in normal individuals and the proportion of both subpopulations were roughly similar in Down's children and normal adults.Keywords
This publication has 27 references indexed in Scilit:
- Down syndrome (DS) peripheral blood contains phenotypically mature CD3+TCRα,β+ cells but abnormal proportions of TCRα,β+, TCRγ,δ+, and CD4+CD45RA+ cells: Evidence for an inefficient release of mature T cells by the DS thymusClinical Immunology and Immunopathology, 1992
- Developmental and maturational changes in human blood lymphocyte subpopulationsImmunology Today, 1992
- Variant CD45R expression with autosomal dominant inheritance affects both helper/inducer (CD4 +) and suppressor/cytotoxic (CD8 +) T cell populationsClinical and Experimental Immunology, 1991
- Interconversion of CD45R subsets of CD4 T cells in vivoNature, 1990
- Immunoregulatory CD4+ CD45R+ suppressor/inducer T lymphocyte subsetsand impaired cell-mediated immunity in patients with Down's syndromeClinical and Experimental Immunology, 1990
- Age-related changes in naive and memory CD4+ T cells in healthy human childrenClinical Immunology and Immunopathology, 1989
- Lymphocyte immunophenotyping at the Centers for Disease Control: The program and special studiesClinical Immunology and Immunopathology, 1989
- Predominance of T cells that express CD45R in the CD4+ helper/inducer lymphocyte subset of neonatesClinical Immunology and Immunopathology, 1989
- Human naive and memory T cells: reinterpretation of helper-inducer and suppressor-inducer subsetsImmunology Today, 1988
- Deficiency of the suppressor inducer subset of T lymphocytes in rheumatoid arthritisArthritis & Rheumatism, 1987