THE STRUCTURE AND FUNCTION OF SMC AND KLEISIN COMPLEXES
- 1 June 2005
- journal article
- review article
- Published by Annual Reviews in Annual Review of Biochemistry
- Vol. 74 (1), 595-648
- https://doi.org/10.1146/annurev.biochem.74.082803.133219
Abstract
▪ Abstract Protein complexes consisting of structural maintenance of chromosomes (SMC) and kleisin subunits are crucial for the faithful segregation of chromosomes during cell proliferation in prokaryotes and eukaryotes. Two of the best-studied SMC complexes are cohesin and condensin. Cohesin is required to hold sister chromatids together, which allows their biorientation on the mitotic spindle. Cleavage of cohesin's kleisin subunit by the separase protease then triggers the movement of sister chromatids into opposite halves of the cell during anaphase. Condensin is required to organize mitotic chromosomes into coherent structures that prevent them from getting tangled up during segregation. Here we describe the discovery of SMC complexes and discuss recent advances in determining how members of this ancient protein family may function at a mechanistic level.Keywords
This publication has 97 references indexed in Scilit:
- DNA Damage Response Pathway Uses Histone Modification to Assemble a Double-Strand Break-Specific Cohesin DomainMolecular Cell, 2004
- Cdc14 Phosphatase Induces rDNA Condensation and Resolves Cohesin-Independent Cohesion during Budding Yeast AnaphaseCell, 2004
- Maintenance of Cohesin at Centromeres after Meiosis I in Budding Yeast Requires a Kinetochore-Associated Protein Related to MEI-S332Current Biology, 2004
- The conserved kinetochore protein shugoshin protects centromeric cohesion during meiosisNature, 2004
- Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculiNature, 2001
- Functional Genomics Identifies Monopolin: A Kinetochore Protein Required for Segregation of Homologs during Meiosis ICell, 2000
- Structural Biology of Rad50 ATPase: ATP-Driven Conformational Control in DNA Double-Strand Break Repair and the ABC-ATPase SuperfamilyCell, 2000
- DPY-27: A chromosome condensation protein homolog that regulates C. elegans dosage compensation through association with the X chromosomeCell, 1994
- A heterodimeric coiled-coil protein required for mitotic chromosome condensation in vitroCell, 1994
- A Mycoplasma hyorhinis protein with sequence similarities to nucleotide-binding enzymesGene, 1991