Cerebral arterial spasm
- 1 May 1976
- journal article
- research article
- Published by Journal of Neurosurgery Publishing Group (JNSPG) in Journal of Neurosurgery
- Vol. 44 (5), 585-593
- https://doi.org/10.3171/jns.1976.44.5.0585
Abstract
✓ In vitro experiments were performed using a small volume chamber to study serotonin-induced contractions of the canine basilar artery. Temperature was found to have a profound effect on the artery's response to serotonin. Raising the temperature to 40° C (104° F) increased the maximum response by 20% and lowering the temperature by 10° C caused a 40% reduction in the maximum contraction. Cumulative log-dose response curves for analogues of serotonin demonstrated a high degree of specificity for the serotonin receptor and large nonphysiological concentrations of serotonin caused relaxation of the contracted artery. Extracellular calcium was shown to be an absolute requirement for serotonin-induced contractions. Extracellular magnesium, in contrast, was shown to inhibit serotonin-induced contractions.Keywords
This publication has 9 references indexed in Scilit:
- Effect of delayed local cooling on experimental spinal cord injuryJournal of Neurosurgery, 1975
- Cerebral arterial spasmJournal of Neurosurgery, 1974
- Cerebral arterial spasmJournal of Neurosurgery, 1974
- Cerebral arterial spasmJournal of Neurosurgery, 1974
- The Effects of Nucleotides on the Expression of β-Adrenergic Adenylate Cyclase Activity in Membranes from Turkey ErythrocytesPublished by Elsevier BV ,1974
- A β-Adrenergic Receptor of the Turkey ErythrocytePublished by Elsevier BV ,1973
- Vascular Smooth Muscle UpdatedCirculation Research, 1973
- Excitation-Contraction Coupling in Rabbit Aorta Studied by the Lanthanum Method for Measuring Cellular Calcium InfluxCirculation Research, 1972
- CUMULATIVE DOSE-RESPONSE CURVES .1. INTRODUCTION TO TECHNIQUE1963