Patterns of developmental trajectories in toddlers with autism spectrum disorder.
- 1 June 2012
- journal article
- Published by American Psychological Association (APA) in Journal of Consulting and Clinical Psychology
- Vol. 80 (3), 477-489
- https://doi.org/10.1037/a0027214
Abstract
Our objective was to follow toddlers referred for risk of autism, using standardized observational measures administered frequently from age 18 months to age 36 months. Sixty-five children who were consecutive referrals and 13 children from other research projects were seen approximately every 2 months, from age 18 months to age 36 months, for standardized assessments and clinical judgments by the same examiner and every 6 months by an examiner blind to previous scores. Thirty children never received an autism spectrum disorder (ASD) diagnosis; 48 children (all referrals) received at least 1 diagnosis of ASD. The best trajectory typology, using Autism Diagnostic Observation Schedule (ADOS) scores, revealed 4 trajectory classes with high probabilities for fit to the most likely class: severe persistent (21%), worsening (21%), improving (19%), and nonspectrum (40%). Classes differed by trajectories in verbal and nonverbal mental ages; never-ever ASD groups differed on Autism Diagnostic Interview-Revised (ADI-R) domain scores and clinician judgments, but improving-worsening trajectory groups did not. The results replicated the findings from studies of infants whose siblings have autism and infants whose siblings do not have autism, suggesting variability in early trajectories and supporting the need for early identification, regular monitoring, and standardized assessments of young children suspected of having ASD.Keywords
Funding Information
- Department of Education (H324 C030112)
- National Institute of Mental Health (R01 MH066496)
- Simons Foundation
This publication has 48 references indexed in Scilit:
- Trajectories of Autism Severity in Children Using Standardized ADOS ScoresPublished by American Academy of Pediatrics (AAP) ,2012
- Longitudinal changes in Scores on the Autism Diagnostic Interview—Revised (ADI-R) in pre-school children with autismAutism, 2011
- The Development of Core Cognitive Skills in Autism: A 3‐Year Prospective StudyChild Development, 2010
- Behavioral Profiles of Affected and Unaffected Siblings of Children with Autism: Contribution of Measures of Mother–Infant Interaction and Nonverbal CommunicationJournal of Autism and Developmental Disorders, 2010
- Adult outcome for children with autismJournal of Child Psychology and Psychiatry, 2004
- The Symptoms of Autism Spectrum Disorders in Adolescence and AdulthoodJournal of Autism and Developmental Disorders, 2003
- Validity and Reliability of the Communication and Symbolic Behavior Scales Developmental Profile With Very Young ChildrenJournal of Speech, Language, and Hearing Research, 2002
- Quantifying the phenotype in autism spectrum disorders.2001
- Subgroups of Children With Autism by Cluster Analysis: A Longitudinal ExaminationJournal of the American Academy of Child & Adolescent Psychiatry, 2000
- The Autism Diagnostic Observation Schedule—Generic: A Standard Measure of Social and Communication Deficits Associated with the Spectrum of AutismJournal of Autism and Developmental Disorders, 2000