Hemorrhagic complications after prasugrel (Effient) therapy for vascular neurointerventional procedures
Open Access
- 3 May 2012
- journal article
- case report
- Published by BMJ in Journal of NeuroInterventional Surgery
- Vol. 5 (4), 337-343
- https://doi.org/10.1136/neurintsurg-2012-010334
Abstract
Dual antiplatelet therapy (DAPT) with aspirin and a thienopyridine (eg, clopidogrel) prevents stent related thromboembolic events in cardiac patients and is frequently utilized during neurointerventional surgery. However, recent data suggest that many patients exhibit clopidogrel resistance. Prasugrel-a newer thienopyridine-lowers the rate of cardiac stent thromboses in clopidogrel non-responders but a paucity of data exist regarding its safety and efficacy in neurointerventional surgery. All patients undergoing neurointerventional surgery by a single interventionalist (CJM) over a 20 month period were retrospectively identified. Charts were reviewed for pre- and post-procedural DAPT regimens, pre-procedural coagulation parameters and procedural complications. 76 patients received pre- and post-procedural DAPT for endovascular treatment of an intracerebral aneurysm, dural arteriovenous fistula or intra/extracranial arterial stenosis. 51 patients underwent 55 total procedures and were treated with aspirin/clopidogrel; 25 patients underwent 31 total procedures and were treated with aspirin/prasugrel. Those patients who received aspirin/prasugrel DAPT were identified pre-procedurally to be clopidogrel non-responders. Both treatment groups had a similar percentage of patients undergoing aneurysm coiling, stent assisted aneurysm coiling, aneurysm Onyx embolization, aneurysm pipeline embolization device treatment, extra/intracranial carotid artery angioplasty and stenting, and dural arteriovenous fistula coil embolization. A total of eight (9.3%) hemorrhagic complications were observed, two (3.6%) in the aspirin/clopidogrel group and six (19.4%) in the aspirin/prasugrel group (p=0.02). No differences were noted in hemorrhage rates for each procedure between treatment groups, nor were there any differences in thrombotic complications between groups. Our results suggest that DAPT with aspirin/prasugrel may predispose to a higher risk of hemorrhage during neurointerventional surgery compared with DAPT with aspirin/clopidogrel.Keywords
This publication has 25 references indexed in Scilit:
- Rate of Nuisance Bleedings and Impact on Compliance to Prasugrel in Acute Coronary SyndromesThe American Journal of Cardiology, 2011
- Managing adverse effects and drug–drug interactions of antiplatelet agentsNature Reviews Cardiology, 2011
- Novel use of prasugrel for intracranial stent thrombosisJournal of NeuroInterventional Surgery, 2011
- Which platelet function test is suitable to monitor clopidogrel responsiveness? A pharmacokinetic analysis on the active metabolite of clopidogrelJournal of Thrombosis and Haemostasis, 2010
- Cost-Effectiveness of Prasugrel Versus Clopidogrel in Patients With Acute Coronary Syndromes and Planned Percutaneous Coronary InterventionCirculation, 2010
- 2009 Focused Updates: ACC/AHA Guidelines for the Management of Patients With ST-Elevation Myocardial Infarction (Updating the 2004 Guideline and 2007 Focused Update) and ACC/AHA/SCAI Guidelines on Percutaneous Coronary Intervention (Updating the 2005 Guideline and 2007 Focused Update): A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice GuidelinesJournal of the American College of Cardiology, 2009
- Pharmacokinetics and Pharmacodynamics of Prasugrel, a Thienopyridine P2Y12 InhibitorPharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 2009
- Comparison of four tests to assess inhibition of platelet function by clopidogrel in stable coronary artery disease patientsEuropean Heart Journal, 2008
- Prevention and Treatment of Thromboembolic and Ischemic Complications Associated with Endovascular Procedures: Part I???Pathophysiological and Pharmacological FeaturesNeurosurgery, 2000
- Prevention and Treatment of Thromboembolic and Ischemic Complications Associated with Endovascular Procedures: Part II???Clinical Aspects and RecommendationsNeurosurgery, 2000