Microstructured glass chip for ion-channel electrophysiology
- 21 September 2001
- journal article
- research article
- Published by American Physical Society (APS) in Physical Review E
- Vol. 64 (4), 040901
- https://doi.org/10.1103/physreve.64.040901
Abstract
We present a technique by which it is possible to produce a planar sensor for ion channel electrophysiology from glass substrates. Apertures with diameters in the low micrometer to submicrometer range are achieved by irradiation of a glass chip with a single heavy ion and subsequent wet track etching. The function of the device is demonstrated by recordings of single channel currents mediated by the model ion channel gramicidin A in lipid bilayers spanning the micromachined aperture.Keywords
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