Role of Creatine Supplementation on Exercise-Induced Cardiovascular Function and Oxidative Stress
Open Access
- 1 January 2009
- journal article
- research article
- Published by Hindawi Limited in Oxidative Medicine and Cellular Longevity
- Vol. 2 (4), 247-254
- https://doi.org/10.4161/oxim.2.4.9415
Abstract
Many degenerative diseases are associated with increased oxidative stress. Creatine has the potential to act as an indirect and direct antioxidant; however, limited data exist to evaluate the antioxidant capabilities of creatine supplementation within in vivo human systems. This study aimed to investigate the effects of oral creatine supplementation on markers of oxidative stress and antioxidant defenses following exhaustive cycling exercise. Following preliminary testing and two additional familiarization sessions, 18 active males repeated two exhaustive incremental cycling trials (T1 and T2) separated by exactly 7 days. The subjects were assigned, in a double-blind manner, to receive either 20 g of creatine (Cr) or a placebo (P) for the 5 days preceding T2. Breath-by-breath respiratory data and heart rate were continually recorded throughout the exercise protocol and blood samples were obtained at rest (preexercise), at the end of exercise (postexercise), and the day following exercise (post24 h). Serum hypdroperoxide concentrations were elevated at postexercise by 17 ± 5% above preexercise values (p = 0.030). However, supplementation did not influence lipid peroxidation (serum hypdroperoxide concentrations), resistance of low density lipoprotein to oxidative stress (t1/2maxLDL oxidation) and plasma concentrations of non-enzymatic antioxidants (retinol, α-carotene, β-carotene, α-tocopherol, γ-tocopherol, lycopene and vitamin C). Heart rate and oxygen uptake responses to exercise were not affected by supplementation. These findings suggest that short-term creatine supplementation does not enhance non-enzymatic antioxidant defence or protect against lipid peroxidation induced by exhaustive cycling in healthy males.Keywords
This publication has 51 references indexed in Scilit:
- Aging is associated with elevated intracellular calcium levels and altered calcium homeostatic mechanisms in hippocampal neuronsNeuroscience Letters, 2007
- Resistance Training With Creatine Monohydrate Improves Upper-Body Strength in Patients With Parkinson Disease: A Randomized TrialNeurorehabilitation and Neural Repair, 2007
- Reliability and Detecting Change Following Short-Term Creatine Supplementation: Comparison of Two-Component Body Composition MethodsJournal of Strength & Conditioning Research, 2007
- Mitochondrial dysfunction and oxidative stress in neurodegenerative diseasesNature, 2006
- Effects of 28 days of beta-alanine and creatine monohydrate supplementation on aerobic power, ventilatory and lactate thresholds, and time to exhaustionAmino Acids, 2006
- Improved Reperfusion and Neuroprotection by Creatine in a Mouse Model of StrokeJournal of Cerebral Blood Flow & Metabolism, 2006
- Does Creatine Supplementation Improve Functional Capacity in Elderly Women?Journal of Strength & Conditioning Research, 2006
- Creatine supplementation during pulmonary rehabilitation in chronic obstructive pulmonary diseaseThorax, 2005
- Direct Antioxidant Properties of CreatineBiochemical and Biophysical Research Communications, 2002
- Alterations in the myocardial creatine kinase system during chronic anaemic hypoxiaCardiovascular Research, 1994