Multicenter Brazilian Study of Oral Candida Species Isolated from Aids Patients
Open Access
- 1 March 2002
- journal article
- research article
- Published by FapUNIFESP (SciELO) in Memórias do Instituto Oswaldo Cruz
- Vol. 97 (2), 253-257
- https://doi.org/10.1590/s0074-02762002000200019
Abstract
Oropharyngeal candidiasis continues to be considered the most common opportunistic disease in Aids patients. This study was designed to investigate species distribution, serotype and antifungal susceptibility profile among Candida spp. isolated from the oral cavity of Aids patients recruited from six Brazilian university centers. Oral swabs from 130 Aids patients were plated onto CHROMagar Candida medium and 142 isolates were recovered. Yeast isolates were identified by classical methods and serotyped using the Candida Check® system-Iatron. Antifungal susceptibility testing was performed according to the NCCLS microbroth assay. C. albicans was the most frequently isolated species (91%), and 70% of the isolates belonged to serotype A. We detected 12 episodes of co-infection (9%), including co-infection with both serotypes of C. albicans. Non-albicans species were isolated from 12 episodes, 50% of them exhibited DDS or resistance to azoles. Otherwise, only 8 out 130 isolates of C. albicans exhibited DDS or resistance to azoles. Brazilian Aids patients are infected mainly by C. albicans serotype A, most of them susceptible to all antifungal drugs.Universidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina Laboratório Especial de MicologiaUniversidade Federal do Rio Grande do Norte Departmento de Microbiologia e ParasitologiaUniversidade de São Paulo Faculdade de Medicina de Ribeirão Preto Departamento de Doenças InfecciosasUniversidade Federal do Paraná Departamento de Medicina Disciplina de Doenças InfecciosasUniversidade Federal de Uberlândia Faculdade de Medicina Departamento de Doenças InfecciosasUniversidade Federal da Bahia Departamento de Doenças InfecciosasUNIFESP, EPM, Laboratório Especial de MicologiaSciELKeywords
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