Impact of Circulating TGF-β and IL-10 on T Cell Cytokines in Patients with Asthma and Tuberculosis
Open Access
- 1 January 2006
- journal article
- Published by XMLink in Journal of Korean Medical Science
- Vol. 21 (1), 30-34
- https://doi.org/10.3346/jkms.2006.21.1.30
Abstract
Regulatory T cells, which stimulate or inhibit the effector functions of distinct T cell subsets, are critical in the control of the immune response. We investigated the effect of TGF-β and IL-10 on T cell subsets according to the Th1/Th2 immune status. Sixty-two patients with asthma and 38 patients with pulmonary tuberculosis were included. Allergy skin tests, tuberculin tests, and chest radiography were performed. The levels of circulating IL-4, IFN-γ, TGF-β1, and IL-10 were measured using ELISA. The level of TGF-β1 was higher in patients with asthma than in those with tuberculosis, but the IL-10 levels were the same between the asthma and tuberculosis groups. Atopy was unrelated to the tuberculin response. The IFN-γ level was correlated with the IL-10 level, and the level of IL-4 was unrelated to the IL-10 or TGF-β1 level. The level of IL-10 was higher in the negative tuberculin reactors than in the positive tuberculin reactors among patients with asthma, and TGF-β1 was higher in the positive tuberculin reactors than in the negative tuberculin reactors among patients with tuberculosis. These results demonstrate that the regulatory effects of circulating TGF-β and IL-10 on T cell cytokines may be different between Th2-type asthma and Th1 tuberculosis.Keywords
This publication has 25 references indexed in Scilit:
- Role of regulatory T cells in allergy and asthmaCurrent Opinion in Immunology, 2003
- Abrogation of TGFβ Signaling in T Cells Leads to Spontaneous T Cell Differentiation and Autoimmune DiseaseImmunity, 2000
- REGULATION OF IMMUNE RESPONSES BY TGF-βAnnual Review of Immunology, 1998
- Atopic versus infectious diseases in childhood: a question of balance?Pediatric Allergy and Immunology, 1997
- The Inverse Association Between Tuberculin Responses and Atopic DisorderScience, 1997
- Changing patterns of childhood infection and ihe rise in allergic diseaseClinical & Experimental Allergy, 1995
- Regulatory T Cell Clones Induced by Oral Tolerance: Suppression of Autoimmune EncephalomyelitisScience, 1994
- Acute Infections in Atopic Dermatitis: A Clue for a Pathogenic Role of a Th1/Th2 Imbalance?Dermatology, 1994
- Natural killer cells are a source of interferon gamma that drives differentiation of CD4+ T cell subsets and induces early resistance to Leishmania major in mice.The Journal of Experimental Medicine, 1993
- Purified protein derivative of Mycobacterium tuberculosis and excretory-secretory antigen(s) of Toxocara canis expand in vitro human T cells with stable and opposite (type 1 T helper or type 2 T helper) profile of cytokine production.JCI Insight, 1991