Variation in antifungal prophylaxis strategies in lung transplantation
- 12 September 2006
- journal article
- research article
- Published by Wiley in Transplant Infectious Disease
- Vol. 8 (4), 213-218
- https://doi.org/10.1111/j.1399-3062.2006.00156.x
Abstract
We conducted a survey of 50 lung transplant centers across the world to evaluate the variation in antifungal prophylaxis practices. These 50 centers performed 63% of the world's lung transplants reported in 2001. Eighty‐six percent (43/50) of the centers responded to the survey. Sixty‐nine percent (30/43) of centers used universal antifungal prophylaxis. Aerosolized amphotericin B deoxycholate (AmBd) alone or in combination with itraconazole was used at 56% (24/43) of centers. The median duration of prophylaxis with aerosolized AmBd and itraconazole was 30 and 90 days, respectively. Seventy‐four percent of the centers surveyed agreed to participate in future research prophylaxis protocols, which they felt should include both diagnostic and therapeutic arms. Our survey is the first documentation of the international variation in antifungal prophylactic strategies in lung transplant recipients, and underscores the need for multicenter, randomized trials of antifungal prophylaxis in lung transplant recipients.Keywords
This publication has 20 references indexed in Scilit:
- A survey of anti-fungal management in lung transplantationThe Journal of Heart and Lung Transplantation, 2004
- Design of Aerosolized Amphotericin B Formulations for Prophylaxis Trials among Lung Transplant RecipientsClinical Infectious Diseases, 2004
- Antifungal Prophylaxis in Solid-Organ Transplant Recipients: Considerations for Clinical Trial DesignClinical Infectious Diseases, 2004
- Issues in Clinical Trials of Prophylaxis of Fungal InfectionsClinical Infectious Diseases, 2004
- Comparative safety of amphotericin B lipid complex and amphotericin B deoxycholate as aerosolized antifungal prophylaxis in lung-transplant recipientsTransplantation, 2004
- The registry of the international society for heart and lung transplantation: twentieth official adult lung and heart–lung transplant report—2003The Journal of Heart and Lung Transplantation, 2003
- Voriconazole versus Amphotericin B for Primary Therapy of Invasive AspergillosisNew England Journal of Medicine, 2002
- Antifungal Prophylaxis During the Early Postoperative Period of Lung TransplantationSocial psychiatry. Sozialpsychiatrie. Psychiatrie sociale, 1999
- Pre-emptive therapy with azoles in lung transplant patientsEuropean Respiratory Journal, 1999
- Aspergillus INFECTION IN SINGLE AND DOUBLE LUNG TRANSPLANT RECIPIENTSTransplantation, 1996