Measuring Tumor Aggressiveness and Targeting Metastatic Lesions with Fluorescent pHLIP
- 23 December 2010
- journal article
- research article
- Published by Springer Science and Business Media LLC in Molecular Imaging & Biology
- Vol. 13 (6), 1146-1156
- https://doi.org/10.1007/s11307-010-0457-z
Abstract
Malignant cancer foci develop acidic extracellular environments. Mild acidic conditions trigger insertion and folding of the pH (low) insertion peptide (pHLIPTM) across a cellular membrane, enabling targeting of such lesions.Keywords
This publication has 31 references indexed in Scilit:
- pH (low) insertion peptide (pHLIP) inserts across a lipid bilayer as a helix and exits by a different pathProceedings of the National Academy of Sciences of the United States of America, 2010
- Cancer as a metabolic diseaseNutrition & Metabolism, 2010
- Accurate Analysis of Tumor Margins Using a Fluorescent pH Low Insertion Peptide (pHLIP)International Journal of Molecular Sciences, 2009
- A Novel Technology for the Imaging of Acidic Prostate Tumors by Positron Emission TomographyCancer Research, 2009
- Bicarbonate Increases Tumor pH and Inhibits Spontaneous MetastasesCancer Research, 2009
- Energetics of peptide (pHLIP) binding to and folding across a lipid bilayer membraneProceedings of the National Academy of Sciences of the United States of America, 2008
- Acid-sensing ion channels (ASICs) as pharmacological targets for neurodegenerative diseasesCurrent Opinion in Pharmacology, 2008
- A Monomeric Membrane Peptide that Lives in Three Worlds: In Solution, Attached to, and Inserted across Lipid BilayersBiophysical Journal, 2007
- Mechanism and uses of a membrane peptide that targets tumors and other acidic tissues in vivoProceedings of the National Academy of Sciences of the United States of America, 2007
- Translocation of molecules into cells by pH-dependent insertion of a transmembrane helixProceedings of the National Academy of Sciences of the United States of America, 2006