Epigenetic Regulation by Long Noncoding RNAs
Top Cited Papers
- 14 December 2012
- journal article
- review article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 338 (6113), 1435-1439
- https://doi.org/10.1126/science.1231776
Abstract
Long Noncoding RNAs: The past 5 years have uncovered thousands of long (>100 nucleotides) noncoding RNAs (lncRNAs) outpacing our understanding of their functions and mechanisms in regulating the genome. Lee (p. 1435 ) reviews the known and suspected means by which these intriguing molecules control gene expression locally and at great distances, considers potential universal roles for lncRNAs, and warns that classifying these intriguing molecules may be quite challenging given their diversity. The very long noncoding RNA, Airn , silences the Igf2r (insulin-like growth factor 2 receptor) imprinted gene cluster in mammals. Latos et al. (p. 1469 ) show in mouse cells that, rather than recruiting enzymes that modify histones to repress the locus, it is the act of transcription of Airn (and not the Airn gene product) that results in the silencing.Keywords
This publication has 79 references indexed in Scilit:
- The lncRNA Malat1 Is Dispensable for Mouse Development but Its Transcription Plays a cis-Regulatory Role in the AdultCell Reports, 2012
- ncRNA- and Pc2 Methylation-Dependent Gene Relocation between Nuclear Structures Mediates Gene Activation ProgramsCell, 2011
- A ceRNA Hypothesis: The Rosetta Stone of a Hidden RNA Language?Cell, 2011
- YY1 Tethers Xist RNA to the Inactive X Nucleation CenterCell, 2011
- The Long Noncoding RNA, Jpx, Is a Molecular Switch for X Chromosome InactivationCell, 2010
- Long Noncoding RNAs with Enhancer-like Function in Human CellsCell, 2010
- A Large Intergenic Noncoding RNA Induced by p53 Mediates Global Gene Repression in the p53 ResponseCell, 2010
- Short RNAs Are Transcribed from Repressed Polycomb Target Genes and Interact with Polycomb Repressive Complex-2Molecular Cell, 2010
- Evolution and Functions of Long Noncoding RNAsCell, 2009
- Functional Demarcation of Active and Silent Chromatin Domains in Human HOX Loci by Noncoding RNAsCell, 2007