Is Coronary Artery Calcification Associated with Vertebral Bone Density in Nondialyzed Chronic Kidney Disease Patients?
Open Access
- 1 June 2011
- journal article
- Published by Ovid Technologies (Wolters Kluwer Health) in Clinical Journal of the American Society of Nephrology
- Vol. 6 (6), 1456-1462
- https://doi.org/10.2215/cjn.10061110
Abstract
Background and objectives Low bone mineral density and coronary artery calcification (CAC) are highly prevalent among chronic kidney disease (CKD) patients, and both conditions are strongly associated with higher mortality. The study presented here aimed to investigate whether reduced vertebral bone density (VBD) was associated with the presence of CAC in the earlier stages of CKD. Design, setting, participants, & measurements Seventy-two nondialyzed CKD patients (age 52 ± 11.7 years, 70% male, 42% diabetics, creatinine clearance 40.4 ± 18.2 ml/min per 1.73 m2) were studied. VBD and CAC were quantified by computed tomography. Results CAC > 10 Agatston units (AU) was observed in 50% of the patients (median 120 AU [interquartile range 32 to 584 AU]), and a calcification score ≥ 400 AU was found in 19% (736 [527 to 1012] AU). VBD (190 ± 52 Hounsfield units) correlated inversely with age (r = −0.41, P < 0.001) and calcium score (r = −0.31, P = 0.01), and no correlation was found with gender, creatinine clearance, proteinuria, lipid profile, mineral parameters, body mass index, and diabetes. Patients in the lowest tertile of VBD had expressively increased calcium score in comparison to the middle and highest tertile groups. In the multiple logistic regression analysis adjusting for confounding variables, low VBD was independently associated with the presence of CAC. Conclusions Low VBD was associated with CAC in nondialyzed CKD patients. The authors suggest that low VBD might constitute another nontraditional risk factor for cardiovascular disease in CKD.Keywords
This publication has 36 references indexed in Scilit:
- Impact of Cardiovascular Calcification in Nondialyzed Patients after 24 Months of Follow-upClinical Journal of the American Society of Nephrology, 2010
- Coronary calcification is associated with lower bone formation rate in CKD patients not yet in dialysis treatmentJournal of Bone and Mineral Research, 2010
- Factors associated with low bone mass in the hemodialysis patients – a cross-sectional correlation studyBMC Musculoskeletal Disorders, 2009
- Association of Changes in Bone Remodeling and Coronary Calcification in Hemodialysis Patients: A Prospective StudyAmerican Journal of Kidney Diseases, 2008
- Relationship of Calcification of Atherosclerotic Plaque and Arterial Stiffness to Bone Mineral Density and Osteoprotegerin in Postmenopausal Women Referred for Osteoporosis ScreeningCalcified Tissue International, 2008
- Hypovitaminosis D in Chronic Kidney DiseaseClinical Journal of the American Society of Nephrology, 2008
- Associations between vascular calcification, arterial stiffness and bone mineral density in chronic kidney diseaseNephrology Dialysis Transplantation, 2007
- Vascular calcification and renal osteodystrophy relationship in chronic kidney diseaseEuropean Journal of Clinical Investigation, 2006
- High prevalence of low bone mineral density in pre-dialysis chronic kidney disease patients: bone histomorphometric analysisClinical Nephrology, 2004
- Spontaneous calcification of arteries and cartilage in mice lacking matrix GLA proteinNature, 1997