Fused transcript of abl and bcr genes in chronic myelogenous leukaemia
- 1 June 1985
- journal article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 315 (6020), 550-554
- https://doi.org/10.1038/315550a0
Abstract
Human chronic myelogenous leukaemia is characterized by a reciprocal translocation between chromosomes 9 and 22 resulting in an abbreviated form of chromosome 22 and the transfer of the abl cellular oncogene from chromosome 9 into the bcr gene of chromosome 22. Characterization of an 8-kilobase RNA specific to chronic myelogenous leukaemia shows it to be a fused transcript of the two genes. The fused protein that would be produced is probably involved in the malignant process.Keywords
This publication has 30 references indexed in Scilit:
- The Chromosomal Basis of Human NeoplasiaScience, 1983
- Cellular RNA homologous to the Abelson murine leukemia virus transforming gene: expression and relationship to the viral sequence.Molecular and Cellular Biology, 1983
- Chromosomal localization of human cellular homologues of two viral oncogenesNature, 1982
- Chromosomal mapping of the simian sarcoma virus onc gene analogue in human cells.Proceedings of the National Academy of Sciences of the United States of America, 1982
- High-efficiency cloning of full-length cDNA.Molecular and Cellular Biology, 1982
- Chromosome Abnormalities in Malignant Hematologic DiseasesAdvances in Cancer Research, 1982
- Chronic Myelogenous Leukemia — New ConceptsNew England Journal of Medicine, 1981
- Chromosomes and causation of human cancer and leukemia: XL. The Ph1 and other translocations in CMLCancer, 1980
- Clustering of aberrations to specific chromosomes in human neoplasmsHereditas, 1978
- A New Consistent Chromosomal Abnormality in Chronic Myelogenous Leukaemia identified by Quinacrine Fluorescence and Giemsa StainingNature, 1973