A population-based survey of the epidemiology of symptom-defined gastroesophageal reflux disease: the Systematic Investigation of Gastrointestinal Diseases in China
Open Access
- 15 August 2010
- journal article
- research article
- Published by Springer Science and Business Media LLC in BMC Gastroenterology
- Vol. 10 (1), 94
- https://doi.org/10.1186/1471-230X-10-94
Abstract
The epidemiology of gastroesophageal reflux disease (GERD) has yet to be investigated using the symptomatic threshold criteria recommended by the Montreal Definition. This study aimed to determine the prevalence of symptom-defined GERD across five regions of China, and to investigate variables associated with GERD. A representative sample of 18 000 adults (aged 18-80 years) were selected equally from rural and urban areas in each region (n = 1800). According to the Montreal Definition, GERD is present when mild symptoms of heartburn and/or regurgitation occur on ≥2 days a week, or moderate-to-severe symptoms of heartburn and/or regurgitation occur on ≥1 day a week. In total, 16 091 participants completed the survey (response rate: 89.4%) and 16 078 responses were suitable for analysis. Applying the Montreal criteria, the prevalence of symptom-defined GERD was 3.1% and varied significantly (p < 0.001) among the five regions (from 1.7% in Guangzhou to 5.1% in Wuhan) and between rural and urban populations (3.8% vs 2.4%). Factors significantly associated with GERD included living in a rural area and a family history of gastrointestinal diseases. This population-based survey found that the prevalence of symptom-defined GERD in China was 3.1%, which is lower than that found in Western countries.Keywords
This publication has 45 references indexed in Scilit:
- Impact of gastroesophageal reflux disease on daily life: the Systematic Investigation of Gastrointestinal Diseases in China (SILC) epidemiological studyHealth and Quality of Life Outcomes, 2010
- Systematic investigation of gastrointestinal diseases in China (SILC): validation of survey methodologyBMC Gastroenterology, 2009
- Collagen type III alpha I is a gastro-oesophageal reflux disease susceptibility gene and a male risk factor for hiatus herniaGut, 2009
- Irritable Bowel Syndrome and Gastroesophageal Reflux Disease in Primary Care: Is There a Link?Digestive Diseases and Sciences, 2008
- Validation of a survey methodology for gastroesophageal reflux disease in ChinaBMC Gastroenterology, 2008
- The Association Between Obesity and GERD: A Review of the Epidemiological EvidenceDigestive Diseases and Sciences, 2008
- Role of obesity in GORD-related disordersGut, 2008
- Lifestyle Factors and Risk for Symptomatic Gastroesophageal Reflux in Monozygotic TwinsGastroenterology, 2007
- Rheumatology in China--brief introduction of the development of Chinese rheumatologyRheumatology, 2006
- Epidemiological study of symptomatic gastroesophageal reflux disease in China: Beijing and ShanghaiChinese Journal of Digestive Diseases, 2000