Metal‐Free Photochemical Aromatic Perfluoroalkylation of α‐Cyano Arylacetates
- 25 March 2014
- journal article
- research article
- Published by Wiley in Angewandte Chemie-International Edition
- Vol. 53 (19), 4921-4925
- https://doi.org/10.1002/anie.201402008
Abstract
We report here an operationally simple protocol for the direct aromatic perfluoroalkylation and trifluoromethylation of α-cyano arylacetates. This metal-free approach, which occurs at ambient temperature and under visible-light irradiation, is driven by the photochemical activity of electron donor–acceptor (EDA) complexes, formed in situ by the interaction of transiently generated enolates and perfluoroalkyl iodides. Preliminary mechanistic studies are reported.Keywords
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