Evidence for two independent prostate cancer risk–associated loci in the HNF1B gene at 17q12
- 31 August 2008
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nature Genetics
- Vol. 40 (10), 1153-1155
- https://doi.org/10.1038/ng.214
Abstract
William Isaacs and colleagues report evidence for a second prostate cancer risk locus in the HNF1B gene at 17q12, ∼26 kb from the previously reported risk locus in this region. The two loci are separated by a recombination hot spot and contribute independently to prostate cancer risk. We carried out a fine-mapping study in the HNF1B gene at 17q12 in two study populations and identified a second locus associated with prostate cancer risk, ∼26 kb centromeric to the first known locus (rs4430796); these loci are separated by a recombination hot spot. We confirmed the association with a SNP in the second locus (rs11649743) in five additional populations, with P = 1.7 × 10−9 for an allelic test of the seven studies combined. The association at each SNP remained significant after adjustment for the other SNP.Keywords
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