Prognostic Evaluation of the Site of Invasion in Pathological Stage T3a Renal Cell Carcinoma
- 23 February 2021
- journal article
- research article
- Published by Anticancer Research USA Inc. in In Vivo
- Vol. 35 (2), 1083-1089
- https://doi.org/10.21873/invivo.12353
Abstract
Background/Aim: To investigate the prognostic values of fat invasion (FI) and renal vein invasion (RVI) in pT3a renal cell carcinoma (RCC), as single factors or concomitant presence. Patients and Methods: We retrospectively reviewed the data of 173 patients who underwent radical or partial nephrectomy for RCC in our Institution. Results: At a median follow-up time of 48 months, patients with RVI showed significantly increased risk of disease recurrence and worse cancer-specific survival (CSS) when compared to those with FI (p=0.007, p=0.022, respectively). Having combined RVI and FI did not show inferior prognosis compared to those with RVI only. In multivariable analysis, RVI was an independent factor for disease recurrence (HR=2.06, 95% CI=1.10-3.87, p=0.024) and CSS (HR=2.46, 95% CI=1.01-6.0, p=0.048). Conclusion: For patients with T3a renal tumors, RVI was associated with inferior prognosis compared to those with FI.Keywords
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