A Single Dose of Marine Chlorella vulgaris Increases Plasma Concentrations of Lutein, β-Carotene and Zeaxanthin in Healthy Male Volunteers
Open Access
- 21 July 2021
- journal article
- research article
- Published by MDPI AG in Antioxidants
- Vol. 10 (8), 1164
- https://doi.org/10.3390/antiox10081164
Abstract
The beneficial health effects of Chlorella vulgaris have been associated with the presence of several nutrients and antioxidants, including carotenoids. However, the in vivo bioavailability of Chlorella is still poorly evaluated. In this work, a human intervention study was conducted in 11 healthy men to evaluate the bioavailability of carotenoids within 3 days after the intake of a single dose (6 g) of dried marine Chlorella vulgaris containing lutein (7.08 mg), β-carotene (1.88 mg) and zeaxanthin (1.47 mg). Subjects were instructed to follow a low carotenoid diet during the experimental phase, starting 1 week earlier. On the day of the experiment, dried microalgae formulated in vegetarian hard capsules were ingested, and blood samples were collected up to 72 h for the analysis of plasma carotenoids concentration by high-performance liquid chromatography with diode-array detection. For all carotenoids, the estimated AUC and Cmax values were significantly different from zero (p < 0.05), indicating that a single dose of marine Chlorella vulgaris increased plasma concentrations of lutein (Cmin-corrected AUC = 1002 µg·h/L, Cmax = 20.4 µg/L), β-carotene (AUC = 1302 µg·h/L, Cmax = 34.9 µg/L) and zeaxanthin (AUC = 122.2 µg·h/L, Cmax = 3.4 µg/L). The bioavailability of other compounds, namely, polyunsaturated fatty acids and trace elements, was also assessed post-prandial for the first time, showing that linoleic acid, docosahexaenoic acid and iodine were absorbed after microalgae intake. These findings support the use of Chlorella vulgaris as a source of carotenoids, PUFA and essential trace elements with associated health benefits.This publication has 36 references indexed in Scilit:
- Farmers’ market use is associated with fruit and vegetable consumption in diverse southern rural communitiesNutrition Journal, 2014
- Olive oil improves the intestinal absorption and bioavailability of lutein in lutein-deficient miceEuropean Journal of Nutrition, 2013
- Salivary Secretory Immunoglobulin a secretion increases after 4-weeks ingestion of chlorella-derived multicomponent supplement in humans: a randomized cross over studyNutrition Journal, 2011
- Potential impact of a 500-mL water bolus and body mass on plasma osmolality dilutionEuropean Journal of Applied Physiology, 2011
- Site-specific concentrations of carotenoids in adipose tissue: relations with dietary and serum carotenoid concentrations in healthy adultsThe American Journal of Clinical Nutrition, 2009
- Bioavailability of Lutein in Chlorella Powder: A Single Ingestion of Chlorella Powder Raises Serum Lutein Concentrations in Healthy Human VolunteersFood Science and Technology Research, 2009
- Major carotenoid composition of Brazilian Valencia orange juice: Identification and quantification by HPLCFood Research International, 2005
- Blockade of Nuclear Factor-κB Signaling Pathway and Anti-Inflammatory Activity of Cardamomin, a Chalcone Analog from Alpinia conchigeraThe Journal of pharmacology and experimental therapeutics, 2005
- Comparison of Lutein Bioavailability from Vegetables and SupplementInternational Journal for Vitamin and Nutrition Research, 2003
- A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATIONCanadian Journal of Biochemistry and Physiology, 1959