Applying Tobacco, Environmental, and Dietary-Related Biomarkers to Understand Cancer Etiology and Evaluate Prevention Strategies
- 12 February 2020
- journal article
- research article
- Published by American Association for Cancer Research (AACR) in Cancer Epidemiology, Biomarkers & Prevention
- Vol. 29 (10), 1904-1919
- https://doi.org/10.1158/1055-9965.epi-19-1356
Abstract
Many human cancers are caused by environmental and lifestyle factors. Biomarkers of exposure and risk developed by our team have provided critical data on internal exposure to toxic and genotoxic chemicals and their connection to cancer in humans. This review highlights our research using biomarkers to identify key factors influencing cancer risk as well as their application to assess the effectiveness of exposure intervention and chemoprevention protocols. The use of these biomarkers to understand individual susceptibility to the harmful effects of tobacco products is a powerful example of the value of this type of research and has provided key data confirming the link between tobacco smoke exposure and cancer risk. Furthermore, this information has led to policy changes that have reduced tobacco use and consequently, the tobacco-related cancer burden. Recent technological advances in mass spectrometry led to the ability to detect DNA damage in human tissues as well as the development of adductomic approaches. These new methods allowed for the detection of DNA adducts in tissues from cancer patients, providing key evidence that exposure to carcinogens leads to DNA damage in the target tissue. These advances will provide valuable insights into the etiological causes of cancer that are not tobacco-related.Funding Information
- NCI (P01 CA138338)
- NCI (R01 CA81301)
- NCI (R01 CA222005)
- NCI (U19 CA157345)
- NCI (U54 DA031659)
- NCI (R01 CA122320)
- NCI (R01 CA220367)
- NCI (R01 ES019564)
- NCI (R33 CA186795)
- NCI (R50 CA211256)
- NCI (R01 CA179246)
- NCI (U01 DA045523)
- NCI (R01 CA220376)
- National Institute of Environmental Health Sciences (U2CES026533)
- NCI (P30 CA77598)
This publication has 198 references indexed in Scilit:
- NanoHPLC-nanoESI+-MS/MS Quantitation of Bis-N7-Guanine DNA–DNA Cross-Links in Tissues of B6C3F1 Mice Exposed to subppm Levels of 1,3-ButadieneAnalytical Chemistry, 2012
- 1,3-Butadiene: Biomarkers and application to risk assessmentChemico-Biological Interactions, 2011
- Metabolism and Biomarkers of Heterocyclic Aromatic Amines in Molecular Epidemiology Studies: Lessons Learned from Aromatic AminesChemical Research in Toxicology, 2011
- Quantitation of a Minor Enantiomer of Phenanthrene Tetraol in Human Urine: Correlations with Levels of Overall Phenanthrene Tetraol, Benzo[a]pyrene Tetraol, and 1-HydroxypyreneChemical Research in Toxicology, 2011
- Reactive species and DNA damage in chronic inflammation: reconciling chemical mechanisms and biological fatesInternational Journal of Cancer, 2010
- Analysis of Acrolein-Derived 1,N2-Propanodeoxyguanosine Adducts in Human Leukocyte DNA from Smokers and NonsmokersChemical Research in Toxicology, 2010
- Analysis of r-7,t-8,9,c-10-Tetrahydroxy-7,8,9,10-tetrahydrobenzo[a]pyrene in Human Urine: A Biomarker for Directly Assessing Carcinogenic Polycyclic Aromatic Hydrocarbon Exposure Plus Metabolic ActivationChemical Research in Toxicology, 2010
- Malondialdehyde−Deoxyguanosine Adduct Formation in Workers of Pathology Wards: The Role of Air Formaldehyde ExposureChemical Research in Toxicology, 2010
- Applying Tobacco Carcinogen and Toxicant Biomarkers in Product Regulation and Cancer PreventionChemical Research in Toxicology, 2010
- Detection and Quantitation of Acrolein-Derived 1,N2-Propanodeoxyguanosine Adducts in Human Lung by Liquid Chromatography-Electrospray Ionization-Tandem Mass SpectrometryChemical Research in Toxicology, 2007