Prognostic Factors in Canine Acute Intervertebral Disc Disease
Open Access
- 26 November 2020
- journal article
- review article
- Published by Frontiers Media SA in Frontiers in Veterinary Science
Abstract
Knowledge of the prognosis of acute spinal cord injury is critical to provide appropriate information for clients and make the best treatment choices. Acute intervertebral disc extrusions (IVDE) are a common cause of pain and paralysis in dogs with several types of IVDE occurring. Important prognostic considerations are recovery of ambulation, return of urinary and fecal continence, resolution of pain and, on the negative side, development of progressive myelomalacia. Initial injury severity affects prognosis as does type of IVDE, particularly when considering recovery of continence. Overall, loss of deep pain perception signals a worse outcome. When considering Hansen type 1 IVDE, the prognosis is altered by the choice of surgical vs. medical therapy. Concentration of structural proteins in the plasma, as well as inflammatory mediators, creatine kinase, and myelin basic protein in the cerebrospinal fluid (CSF) can provide additional prognostic information. Finally, cross-sectional area and length of T2 hyperintensity and loss of HASTE signal on MRI have been associated with outcome. Future developments in plasma and imaging biomarkers will assist in accurate prognostication and optimization of patient management.Keywords
This publication has 103 references indexed in Scilit:
- Acute adverse events associated with ventral slot decompression in 546 dogs with cervical intervertebral disc diseaseVeterinary Surgery, 2013
- Quantitative Magnetic Resonance Imaging CharacteristicsJournal of Spinal Disorders & Techniques, 2012
- Microglial Contribution to Secondary Injury Evaluated in a Large Animal Model of Human Spinal Cord TraumaJournal of Neurotrauma, 2012
- The Cutaneous Trunci Muscle Reflex: A Predictor of Recovery in Dogs with Acute Thoracolumbar Myelopathies Caused by Intervertebral Disc ExtrusionsVeterinary Surgery, 2011
- Association of Cerebrospinal Fluid Analysis Findings with Clinical Signs and Outcome in Acute Nonambulatory Thoracolumbar Disc Disease in DogsJournal of Veterinary Internal Medicine, 2011
- Magnetic Resonance Imaging in Dogs with Neurologic Impairment Due to Acute Thoracic and Lumbar Intervertebral Disk HerniationJournal of Veterinary Internal Medicine, 2009
- Evaluation of the Success of Medical Management for Presumptive Cervical Intervertebral Disk Herniation in DogsVeterinary Surgery, 2007
- Evaluation of the Success of Medical Management for Presumptive Thoracolumbar Intervertebral Disk Herniation in DogsVeterinary Surgery, 2007
- MYELOGRAPHY IN THE DOG: REVIEW OF PATIENTS WITH CONTRAST MEDIUM IN THE CENTRAL CANALVeterinary Radiology & Ultrasound, 1993
- Prognostic Application of Cortical Evoked Responses in Dogs with Spinal Cord InjuryVeterinary Surgery, 1977