Gasdermin family: a promising therapeutic target for cancers and inflammation-driven diseases
- 1 September 2020
- journal article
- review article
- Published by Wiley in Journal of Cell Communication and Signaling
- Vol. 14 (3), 293-301
- https://doi.org/10.1007/s12079-020-00564-5
Abstract
This review focuses on current advances in researches of gasdermin family. The distinctive expression patterns and biological roles of members in this family were discussed. Most of them exhibit pore-forming activity on cell membranes and are executors for programmed cell death with cytokines release, and play roles in cancers and inflammation-driven diseases. Therefore, they can be used as potential therapeutic targets to treat related diseases.Funding Information
- National Natural Science Foundation of China (81573733, 81873130, 81804025)
- Tianjin Science and Technology Committee (18JCYBJC94500)
- Natural Science Foundation of Tianjin Municipal Science and Technology Commission (2017KJ164)
- National Natural Science Foundation of China (81704056)
- Jiangxi Municipal Natural Science Foundation (20171ACB21075)
- Jiangxi Municipal Natural Science Foundation (20181BAB205073)
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