Increased Platelet Aggregation in Children and Adolescents with Sleep-disordered Breathing
- 1 December 2020
- journal article
- research article
- Published by American Thoracic Society in American Journal of Respiratory and Critical Care Medicine
- Vol. 202 (11), 1560-1566
- https://doi.org/10.1164/rccm.201911-2229oc
Abstract
Objective: Sleep disordered breathing (SDB) is associated with increased vascular resistance in children and adults. Persistent increased vascular resistance damages vascular endothelial cells—a marker of which is increased platelet activation. This study compared whole blood impedance platelet aggregation in children diagnosed clinically as SDB warranting adenotonsillectomy and healthy controls. Methods and Results: Thirty children clinically diagnosed by experienced pediatric otolaryngologists as having SDB warranting intervention were recruited from adenotonsillectomy waitlists and 20 healthy children from the community underwent overnight polysomnography to determine SDB severity (Obstructive Apnea Hypopnea Index (OAHI)). Snoring frequency was collected from parents. In the morning, a fasting blood sample was taken and whole blood platelet aggregation was measured. Children with SDB exhibited increased platelet aggregation to thrombin receptor activating peptide (TRAP) (SDB = 114.8 vs Control = 98.0 AU, p < 0.05); collagen antibody (COL) (96.7 vs 82.2 AU, p < 0.05); and an increased trend in adenosine diphosphate antibody (ADP) (82.3 vs 69.2 AU, p < 0.07); but not aspirin dialuminate (ASP) (82.1 vs 79.5 AU, p > 0.05). No significant association was observed between either OAHI and any aggregation parameter, but parental report of snoring was positively associated with TRAP aggregation (Kendall’s τ-c = 0.23, p < 0.05). Conclusion: The finding of increased platelet aggregation is consistent with endothelial damage. This suggests that the profile of cardiovascular changes noted in adults with SDB may also occur in children with SDB.Keywords
This publication has 55 references indexed in Scilit:
- Physiological effects of obstructive sleep apnea syndrome in childhoodRespiratory Physiology & Neurobiology, 2013
- Rules for Scoring Respiratory Events in Sleep: Update of the 2007 AASM Manual for the Scoring of Sleep and Associated EventsSleep Medicine, 2012
- Thrombin Generation in Hemorrhage Control and Vascular OcclusionCirculation, 2011
- Brachial artery hyperaemic blood flow velocity and left ventricular geometryJournal of Human Hypertension, 2011
- Endothelial Progenitor Cells and Vascular Dysfunction in Children with Obstructive Sleep ApneaAmerican Journal of Respiratory and Critical Care Medicine, 2010
- Multiplate®Whole Blood Impedance Point of Care Aggregometry: Preliminary Reference Values in Healthy Infants, Children and AdolescentsKlinische Padiatrie, 2010
- Circulating cell-derived microparticles in patients with minimally symptomatic obstructive sleep apnoeaEuropean Respiratory Journal, 2008
- Hemodynamic shear stress and the endothelium in cardiovascular pathophysiologyNature Clinical Practice Cardiovascular Medicine, 2008
- Increased Cerebral Blood Flow Velocity in Children With Mild Sleep-Disordered Breathing: A Possible Association With Abnormal Neuropsychological FunctionPEDIATRICS, 2006
- Activated CD8+ T-lymphocytes in obstructive sleep apnoeaEuropean Respiratory Journal, 2005