Ligustilide improves aging-induced memory deficit by regulating mitochondrial related inflammation in SAMP8 mice
Open Access
- 29 February 2020
- journal article
- research article
- Published by Impact Journals, LLC in Aging
- Vol. 12 (4), 3175-3189
- https://doi.org/10.18632/aging.102793
Abstract
Alzheimer's disease (AD) is an age-related neurodegenerative disease. The main active component in Angelica sinensis, ligustilide, has been reported to have the protective effect on AD. Whether ligustilide could protect against age-induced dementia is still unknown. In this study, we used an aging model, SAMP8 mice to investigate the neuroprotective effect of ligustilide. The behavioral tests (Morris water maze, object recognition task, open field test and elevated plus maze) results showed that ligustilide could improve the memory deficit in SAMP8 mice. For mechanism study, we found that the protein level of P-Drp1 (fission) was decreased and the levels of Mfn1 and Mfn2 (fusion) were increased after ligustilide treatment in animals and cells. Ligustilide increased PAMPK and ATP levels. Malondialdehyde and superoxide dismutase activity results indicated that ligustilide exerts antioxidant effects by reducing the level of oxidative stress markers. In addition, ligustilide improved neural function and alieved apoptosis and neuroinflammation. These findings have shown that ligustilide treatment improves mitochondrial function in SAMP8 mice, and improves memory loss.Keywords
This publication has 44 references indexed in Scilit:
- Progressive thermopreconditioning attenuates rat cardiac ischemia/reperfusion injury by mitochondria-mediated antioxidant and antiapoptotic mechanismsThe Journal of Thoracic and Cardiovascular Surgery, 2014
- The CAMKK2-AMPK Kinase Pathway Mediates the Synaptotoxic Effects of Aβ Oligomers through Tau PhosphorylationNeuron, 2013
- Metabolism of inflammation limited by AMPK and pseudo-starvationNature, 2013
- Ligustilide alleviates brain damage and improves cognitive function in rats of chronic cerebral hypoperfusionJournal of Ethnopharmacology, 2012
- Alzheimer Disease: New Concepts on Its Neurobiology and the Clinical Role Imaging Will PlayRadiology, 2012
- Apomorphine treatment in Alzheimer mice promoting amyloid‐β degradationAnnals of Neurology, 2010
- Protective effect of Z-ligustilide against amyloid β-induced neurotoxicity is associated with decreased pro-inflammatory markers in rat brainsPharmacology Biochemistry and Behavior, 2009
- A detailed ethological analysis of the mouse open field test: effects of diazepam, chlordiazepoxide and an extremely low frequency pulsed magnetic fieldNeuroscience & Biobehavioral Reviews, 2001
- Senescence-accelerated mouse (SAM): A novel murine model of senescenceExperimental Gerontology, 1997
- Aging: A Theory Based on Free Radical and Radiation ChemistryJournal of Gerontology, 1956