Assessing episodic memory in rodents using spontaneous object recognition tasks
- 7 December 2022
- journal article
- review article
- Published by Portland Press Ltd. in Emerging Topics in Life Sciences
- Vol. 6 (5), 541-554
- https://doi.org/10.1042/etls20220010
Abstract
Models of episodic memory are successfully established using spontaneous object recognition tasks in rodents. In this review, we present behavioral techniques devised to investigate this type of memory, emphasizing methods based on associations of places and temporal order of items explored by rats and mice. We also provide a review on the areas and circuitry of the medial temporal lobe underlying episodic-like memory, considering that a large number of neurobiology data derived from these protocols. Although spontaneous recognition tasks are commonplace in this field, there is need for careful evaluation of factors affecting animal performance. Such as the ongoing development of tools for investigating the neural basis of memory, efforts should be put in the refinement of experimental designs, in order to provide reliable behavioral evidence of this complex mnemonic system.Keywords
This publication has 101 references indexed in Scilit:
- The evolution of episodic memoryProceedings of the National Academy of Sciences of the United States of America, 2013
- Lateral entorhinal cortex is critical for novel object‐context recognitionHippocampus, 2013
- The neural basis of nonvisual object recognition memory in the rat.Behavioral Neuroscience, 2013
- Perspectives on Episodic-Like and Episodic MemoryFrontiers in Behavioral Neuroscience, 2013
- Interfering with Fos expression in rat perirhinal cortex impairs recognition memoryHippocampus, 2012
- The novel object recognition memory: neurobiology, test procedure, and its modificationsCognitive Processing, 2011
- Distinct contributions of the hippocampus and medial prefrontal cortex to the “what–where–when” components of episodic-like memory in miceBehavioural Brain Research, 2010
- Role of CA3 and CA1 subregions of the dorsal hippocampus on temporal processing of objectsNeurobiology of Learning and Memory, 2007
- Microstructure of a spatial map in the entorhinal cortexNature, 2005
- The hippocampus as a spatial map. Preliminary evidence from unit activity in the freely-moving ratBrain Research, 1971