Conditional knock out of transcription factor CTCF in excitatory neurons induces cognitive deficiency
Open Access
- 5 January 2021
- journal article
- research article
- Published by Springer Science and Business Media LLC in Molecular Brain
- Vol. 14 (1), 1-4
- https://doi.org/10.1186/s13041-020-00716-z
Abstract
CCCTC-binding factor (CTCF) is a transcription factor that is involved in organizing chromatin structure. A reduction of CTCF expression is known to develop distinct clinical features. Furthermore, conditional knock out (cKO) study revealed reactive gliosis of astrocytes and microglia followed by age-dependent cell death in the excitatory neurons of CTCF cKO mice. To assess the cognitive ability in CTCF cKO mice of over 20 weeks of age, we examined pairwise discrimination (PD), PD reversal learning (PDr), and different paired-associate learning (dPAL) tasks using a touch screen apparatus. We found cognitive impairment in dPAL touch screen tests, suggesting that prolonged Ctcf gene deficiency results in cognitive deficits.Keywords
Funding Information
- National Research Foundation of Korea (NRF-2019R1F1A1063932, NRF-2012R1A3A1050385)
- L’Oreal Korea-UNESCO Women in Science fellowship
- L’Oreal-UNESCO Rising Talent Award
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