Perphenazine Attenuates the Pro-Inflammatory Responses in Mouse Models of Th2-Type Allergic Dermatitis
Open Access
- 2 May 2020
- journal article
- research article
- Published by MDPI AG in International Journal of Molecular Sciences
- Vol. 21 (9), 3241
- https://doi.org/10.3390/ijms21093241
Abstract
Developing dermatitis therapeutics has been faced with challenges including adverse effects of topical steroid and high cost of new developing drugs. Here, we found the expression levels of dopamine receptor D2 is higher in skin biopsies of dermatitis patients and an oxazolone-induced animal model of dermatitis. We used perphenazine, an FDA-approved dopamine receptor antagonist to determine the therapeutic effect. Two different animal models including 12-o-tetradecanoylphorbol-13-acetate (TPA) and oxazolone (OXA)-induced dermatitis were employed. TPA and OXA-mediated ear swelling was attenuated by perphenazine. Moreover, perphenazine inhibited infiltrated mast cells into lesion area. We found levels of serum IgE, histamine and cytokines are decreased in mice cotreated with perphenazine and OXA compared to OXA-treated mice. Overall, this is a first study showing that the FDA-approved, anti-psychotic drug, perphenazine, alleviates animal models of dermatitis.This publication has 45 references indexed in Scilit:
- Atopic dermatitis: a disease of altered skin barrier and immune dysregulationImmunological Reviews, 2011
- E3 ubiquitin ligase Hades negatively regulates the exonuclear function of p53Cell Death & Differentiation, 2011
- Dopamine D2–Receptor Antagonists Ameliorate Indomethacin-Induced Small Intestinal Ulceration in Mice by Activating α7 Nicotinic Acetylcholine ReceptorsJournal of Pharmacological Sciences, 2011
- D1 and D2 Dopamine Receptor-mediated Inhibition of Activated Normal T Cell Proliferation Is Lost in Jurkat T Leukemic CellsOnline Journal of Public Health Informatics, 2010
- The immunoregulatory role of dopamine: An updateBrain, Behavior, and Immunity, 2010
- Triad 1 induces apoptosis by p53 activationFEBS Letters, 2010
- A module-based analytical strategy to identify novel disease-associated genes shows an inhibitory role for interleukin 7 Receptor in allergic inflammationBMC Systems Biology, 2009
- Animal Models of Atopic DermatitisJournal of Investigative Dermatology, 2009
- Increased expression of aquaporin 3 in atopic eczemaAllergy, 2006
- Adverse effects of topical glucocorticosteroidsJournal of the American Academy of Dermatology, 2006