Life, death, and autophagy in cancer: NF-κB turns up everywhere
Open Access
- 30 March 2020
- journal article
- review article
- Published by Springer Science and Business Media LLC in Cell Death & Disease
- Vol. 11 (3), 1-14
- https://doi.org/10.1038/s41419-020-2399-y
Abstract
Escaping programmed cell death is a hallmark of cancer. NF-κB transcription factors are key regulator of cell survival and aberrant NF-κB signaling has been involved in the pathogenesis of most human malignancies. Although NF-κB is best known for its antiapoptotic role, other processes regulating the life/death balance, such as autophagy and necroptosis, seem to network with NF-κB. This review discusses how the reciprocal regulation of NF-κB, autophagy and programmed cell death affect cancer development and progression.Keywords
Funding Information
- Ministero dell'Istruzione, dell'Università e della Ricerca (2017WLKYAM_1, 2017WLKYAM_3)
- Ministero dell'Istruzione, dell'Università e della Ricerca
- RCUK | Medical Research Council (MR/L005069/1)
- NIHR Imperial (BRC) Push for Impact Award WIIS_P81135
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