SWI/SNF Complex Mutations Promote Thyroid Tumor Progression and Insensitivity to Redifferentiation Therapies
Open Access
- 14 December 2020
- journal article
- research article
- Published by American Association for Cancer Research (AACR) in Cancer Discovery
- Vol. 11 (5), 1158-1175
- https://doi.org/10.1158/2159-8290.cd-20-0735
Abstract
Mutations in components of the BAF (mammalian SWI/SNF) complex promoted thyroid cancer, reduced expression of thyroid differentiation genes, blocked the redifferentiation effects of MAPK inhibition, and reduced radioiodine treatment efficacy in vivo.Other Versions
Funding Information
- NIH (CA50706-23)
- NIH (CA184724-01A1)
- NIH (DK-15070)
- NCI (P50 CA 172012-01)
- Translational Research Oncology Training program (5T32CA160001)
- NCI (P30 CA08748)
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