Influence of Resistance Training Proximity-to-Failure on Skeletal Muscle Hypertrophy: A Systematic Review with Meta-analysis
Open Access
- 5 November 2022
- journal article
- review article
- Published by Springer Science and Business Media LLC in Sports Medicine
- Vol. 53 (3), 649-665
- https://doi.org/10.1007/s40279-022-01784-y
Abstract
Background and Objective This systematic review with meta-analysis investigated the influence of resistance training proximity-to-failure on muscle hypertrophy. Methods Literature searches in the PubMed, SCOPUS and SPORTDiscus databases identified a total of 15 studies that measured muscle hypertrophy (in healthy adults of any age and resistance training experience) and compared resistance training performed to: (A) momentary muscular failure versus non-failure; (B) set failure (defined as anything other than momentary muscular failure) versus non-failure; or (C) different velocity loss thresholds. Results There was a trivial advantage for resistance training performed to set failure versus non-failure for muscle hypertrophy in studies applying any definition of set failure [effect size=0.19 (95% confidence interval 0.00, 0.37), p=0.045], with no moderating effect of volume load (p=0.884) or relative load (p=0.525). Given the variability in set failure definitions applied across studies, sub-group analyses were conducted and found no advantage for either resistance training performed to momentary muscular failure versus non-failure for muscle hypertrophy [effect size=0.12 (95% confidence interval −0.13, 0.37), p=0.343], or for resistance training performed to high (>25%) versus moderate (20–25%) velocity loss thresholds [effect size=0.08 (95% confidence interval −0.16, 0.32), p=0.529]. Conclusion Overall, our main findings suggest that (i) there is no evidence to support that resistance training performed to momentary muscular failure is superior to non-failure resistance training for muscle hypertrophy and (ii) higher velocity loss thresholds, and theoretically closer proximities-to-failure do not always elicit greater muscle hypertrophy. As such, these results provide evidence for a potential non-linear relationship between proximity-to-failure and muscle hypertrophy.Keywords
Funding Information
- Deakin University
This publication has 42 references indexed in Scilit:
- Recovery of central and peripheral neuromuscular fatigue after exerciseJournal of Applied Physiology, 2017
- Heavier and lighter load resistance training to momentary failure produce similar increases in strength with differing degrees of discomfortMuscle & Nerve, 2017
- Effects of velocity loss during resistance training on athletic performance, strength gains and muscle adaptationsScandinavian Journal of Medicine & Science in Sports, 2016
- Novel Resistance Training–Specific Rating of Perceived Exertion Scale Measuring Repetitions in ReserveJournal of Strength & Conditioning Research, 2016
- Is repetition failure critical for the development of muscle hypertrophy and strength?Scandinavian Journal of Medicine & Science in Sports, 2015
- Validation of a new tool for the assessment of study quality and reporting in exercise training studiesJBI Evidence Implementation, 2015
- Conducting Meta-Analyses inRwith themetaforPackageJournal of Statistical Software, 2010
- Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA StatementJournal of Clinical Epidemiology, 2009
- Skeletal Muscle Fatigue: Cellular MechanismsPhysiological Reviews, 2008
- Skeletal muscle adaptations consequent to long-term heavy resistance exerciseMedicine & Science in Sports & Exercise, 1988