Impact of Tigecycline on C. difficile Outcomes: Case Series and Propensity-Matched Retrospective Study
Open Access
- 1 June 2022
- journal article
- research article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 66 (6), e0000122
- https://doi.org/10.1128/aac.00001-22
Abstract
This case series and propensity-matched cohort study on the use of tigecycline in Clostridioides difficile infection (CDI) evaluated the effect of tigecycline on 30-day mortality. Adjusted for ATLAS Score, hypotension, treatment time period, and serum lactate, tigecycline did not significantly improve 30-day mortality (odds ratio: 0.89; 95% confidence interval: 0.25-3.12; P = 0.853). A randomized controlled trial is needed to determine efficacy and safety of tigecycline in severe or refractory CDI.Funding Information
- HHS | NIH | National Center for Advancing Translational Sciences (UL1TR003015, KL2TR003016)
- HHS | National Institutes of Health (K23AI163368)
- HHS | National Institutes of Health (AI145322)
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