Immunomodulator Activity of Effervescent Granule of Wualae Fruit (Etlingera elatior (Jack) R.M. Smith) Based on Specific Phagocytic Activity
Open Access
- 14 November 2019
- journal article
- Published by Universitas Muhammadiyah Palangkaraya in Borneo Journal of Pharmacy
- Vol. 2 (2), 35-40
- https://doi.org/10.33084/bjop.v2i2.868
Abstract
The previous study reported that Etlingera elatior (Wualae) has activity as immunostimulant with dose at 300 mg/kg BW and 400 mg/kg BW. Formulating natural product into effervescent granule (GE) can increase practicality and interest to consume traditional medicine. This study aims to investigate the immunostimulant activity of Wualae ethanolic extract in the effervescent granule. Wualae was macerated with ethanol then formulated into effervescent granule at dose 300 mg/kgBW and 400 mg/kgBW. Formulations were evaluated. Animals were divided into 4 groups and treated with: group I (positive control); group II (negative control); group III (GE dose at 300mg/kgBW); and group IV (GE at dose 400mg/kgBW) for 7 days and at days 8, groups were infected by Staphylococcus aureus intraperitoneally. Immunostimulant activity was measured by calculating the Specific Phagocytic Activity (SPA) of macrophage. Data collected from the evaluation and measurement of the SPA then analyzed using SPSS. Results from the evaluation were considered good except the moisture content of effervescent granule. Results from SPA was found that effervescent granule at dose 300 mg/kgBW and at dose 400 mg/kgBW have 26.33% and 32.5% consecutively with significance 0.02 (p<0.05). Thus, effervescent granule has comparable phagocytosis activity with positive control.Keywords
Funding Information
- Kementerian Riset Teknologi Dan Pendidikan Tinggi Republik Indonesia
This publication has 12 references indexed in Scilit:
- Preparation and Characterization of the Biological Compound Effervescent Granule of Calcium AcetateCurrent Pharmaceutical Biotechnology, 2019
- Immunomodulatory Effects of Flavonoids: Possible Induction of T CD4+ Regulatory Cells Through Suppression of mTOR Pathway Signaling ActivityFrontiers in Immunology, 2019
- Formulation and evaluation of effervescent tablets: a reviewJournal of Drug Delivery and Therapeutics, 2018
- FORMULASI TABLET EFFERVESCENT EKSTRAK KULIT BUAH DELIMA PUTIH (Punica granatum var. album) DENGAN VARIASI ASAM SITRAT DAN ASAM TARTRATPharmasipha : Pharmaceutical Journal of Islamic Pharmacy, 2018
- Flavonoids, Inflammation and Immune SystemNutrients, 2016
- UJI EFEK IMUNOSTIMULASI EKSTRAK ETANOL HERBA CIPLUKAN (Physalis angulata L.) TERHADAP AKTIVITAS DAN KAPASITAS FAGOSITOSIS SEL MAKROFAG PADA MENCIT PUTIH BETINASCIENTIA : Jurnal Farmasi dan Kesehatan, 2016
- Macrophage Cytokines: Involvement in Immunity and Infectious DiseasesFrontiers in Immunology, 2014
- Phytochemistry and Pharmacological Properties of Etlingera elatior: A ReviewPharmacognosy Journal, 2011
- Pharmacological activity, phytochemical analysis and toxicity of methanol extract of Etlingera elatior (torch ginger) flowersAsian Pacific Journal of Tropical Medicine, 2010
- Macrophage activation, phagocytosis and intracellular calcium oscillations induced by scorpion toxins fromTityus serrulatusClinical and Experimental Immunology, 2008