Expression and Function of Eicosanoid-Producing Cytochrome P450 Enzymes in Solid Tumors
Open Access
- 9 June 2020
- journal article
- review article
- Published by Frontiers Media SA in Frontiers in Pharmacology
- Vol. 11, 828
- https://doi.org/10.3389/fphar.2020.00828
Abstract
Oxylipins derived from the oxidation of polyunsaturated fatty acids (PUFAs) act as important paracrine and autocrine signaling molecules. A subclass of oxylipins, the eicosanoids, have a broad range of physiological outcomes in inflammation, the immune response, cardiovascular homeostasis, and cell growth regulation. Consequently, eicosanoids are implicated in the pathophysiology of various diseases, most notably cancer, where eicosanoid mediated signaling is involved in tumor development, progression, and angiogenesis. Cytochrome P450s (CYPs) are a superfamily of heme monooxygenases generally involved in the clearance of xenobiotics while a subset of isozymes oxidize PUFAs to eicosanoids. Several eicosanoid forming CYPs are overexpressed in tumors, elevating eicosanoid levels and suggesting a key function in tumorigenesis and progression of tumors in the lung, breast, prostate, and kidney. This review summarizes the current understanding of CYPs' involvement in solid tumor etiology and progression providing supporting public data for gene expression from The Cancer Genome Atlas.Funding Information
- National Institutes of Health (5 R01 HL 130880-04)
This publication has 149 references indexed in Scilit:
- Effects of Ellagic Acid on Angiogenic Factors in Prostate Cancer CellsCancers, 2013
- Fatty Acid Metabolites in Rapidly Proliferating Breast CancerPLOS ONE, 2013
- Targeting 20-HETE producing enzymes in cancer – rationale, pharmacology, and clinical potentialOncoTargets and Therapy, 2013
- Role of soluble epoxide hydrolase phosphatase activity in the metabolism of lysophosphatidic acidsBiochemical and Biophysical Research Communications, 2012
- Cancer Risks Associated With Germline Mutations in MLH1, MSH2, and MSH6 Genes in Lynch SyndromeJAMA, 2011
- Cytochrome P4501A2 phenotype and bladder cancer risk: The Shanghai bladder cancer studyInternational Journal of Cancer, 2011
- Cytochrome P450 ω-hydroxylase promotes angiogenesis and metastasis by upregulation of VEGF and MMP-9 in non-small cell lung cancerCancer Chemotherapy and Pharmacology, 2010
- Vascular Pharmacology of Epoxyeicosatrienoic AcidsAdvances in Pharmacology, 2010
- Epoxyeicosatrienoic acids and endothelium-dependent responsesPflügers Archiv - European Journal of Physiology, 2010
- Inflammation and cancerNature, 2002