Gain-of-Function Genetic Alterations of G9a Drive Oncogenesis
Open Access
- 8 April 2020
- journal article
- research article
- Published by American Association for Cancer Research (AACR) in Cancer Discovery
- Vol. 10 (7), 980-997
- https://doi.org/10.1158/2159-8290.cd-19-0532
Abstract
Amplification of or activating mutations in the histone methyltransferase–encoding gene EHMT2 reduced DKK1-mediated inhibition of the WNT pathway to promote melanoma development.Other Versions
Funding Information
- NIH (5P01 CA163222, 1R01CA222871, 5R01AR072304, 5R01 AR043369-22)
- Melanoma Research Alliance
- Dr. Miriam and Sheldon G. Adelson Medical Research Foundation
- Japan Society for the Promotion of Science
- NIH (R01HD088626, R01GM122749)
- Cancer Research UK (C588/A19167, C8216/A6129, C588/A10721)
- NIH (CA83115)
- Horizon 2020 (641458)
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