Light-mediated control of activity in a photosensitive foldamer that mimics an esterase
- 29 January 2021
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Chemical Communications
- Vol. 57 (18), 2269-2272
- https://doi.org/10.1039/d0cc08309g
Abstract
We report a catalytic foldamer in which a fumaramide chromophore links a Ser residue to a helical domain that contains within its sequence the residues His and Asp. Photoisomerization of the fumaramide chromophore (with E geometry) to the corresponding maleamide (with Z geometry) brings together a ‘catalytic triad’ of Ser, His, and Asp, triggering esterase activity that is absent in the fumaramide isomer. The fumaramide/maleamide linker thus acts as a light-sensitive switchable cofactor for activation of catalytic activity in short foldamers.Keywords
Funding Information
- Università degli Studi di Padova (Grant PDiSC06BIRD2018-UNIPD)
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