Mitochondrial Dysfunction and Permeability Transition in Neonatal Brain and Lung Injuries
Open Access
- 5 March 2021
- Vol. 10 (3), 569
- https://doi.org/10.3390/cells10030569
Abstract
This review discusses the potential mechanistic role of abnormally elevated mitochondrial proton leak and mitochondrial bioenergetic dysfunction in the pathogenesis of neonatal brain and lung injuries associated with premature birth. Providing supporting evidence, we hypothesized that mitochondrial dysfunction contributes to postnatal alveolar developmental arrest in bronchopulmonary dysplasia (BPD) and cerebral myelination failure in diffuse white matter injury (WMI). This review also analyzes data on mitochondrial dysfunction triggered by activation of mitochondrial permeability transition pore(s) (mPTP) during the evolution of perinatal hypoxic-ischemic encephalopathy. While the still cryptic molecular identity of mPTP continues to be a subject for extensive basic science research efforts, the translational significance of mitochondrial proton leak received less scientific attention, especially in diseases of the developing organs. This review is focused on the potential mechanistic relevance of mPTP and mitochondrial dysfunction to neonatal diseases driven by developmental failure of organ maturation or by acute ischemia-reperfusion insult during development.Funding Information
- National Institutes of Health (NS099109, NS100850, PO AG14930)
This publication has 101 references indexed in Scilit:
- Nelfinavir Inhibits Intra-Mitochondrial Calcium Influx and Protects Brain against Hypoxic-Ischemic Injury in Neonatal MicePLOS ONE, 2013
- Arrested preoligodendrocyte maturation contributes to myelination failure in premature infantsAnnals of Neurology, 2011
- The developing oligodendrocyte: key cellular target in brain injury in the premature infantInternational Journal of Developmental Neuroscience, 2011
- A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporterNature, 2011
- Injury and differentiation following inhibition of mitochondrial respiratory chain complex IV in rat oligodendrocytesGlia, 2010
- Oligodendroglial differentiation induces mitochondrial genes and inhibition of mitochondrial function represses oligodendroglial differentiationMitochondrion, 2010
- The state of systemic circulation, collapsed or preserved defines the need for hyperoxic or normoxic resuscitation in neonatal mice with hypoxia–ischemiaResuscitation, 2010
- Mitochondrial calcium and the permeability transition in cell deathBiochimica et Biophysica Acta (BBA) - Bioenergetics, 2009
- Cyclophilin D-dependent mitochondrial permeability transition regulates some necrotic but not apoptotic cell deathNature, 2005
- THE MITOCHONDRIAL PERMEABILITY TRANSITIONBiochimica et Biophysica Acta (BBA) - Reviews on Biomembranes, 1995