Association between disease progression and depression onset in persons with radiographic knee osteoarthritis
Open Access
- 31 October 2020
- journal article
- research article
- Published by Oxford University Press (OUP) in Rheumatology
- Vol. 59 (11), 3390-3399
- https://doi.org/10.1093/rheumatology/keaa141
Abstract
Objectives. Osteoarthritis (OA) disease progression may lead to deteriorating psychosocial function, but it is unclear what aspects of disease severity are related to the onset of depression. This study assessed which components of OA disease progression cumulatively contribute to depression onset in persons with radiographic knee OA. Methods. Osteoarthritis Initiative participants (n = 1 6 51) with radiographic disease (Kellgren-Lawrence grade >= 2) in one or both knees and below the screening threshold for probable depression [Center for Epidemiological Studies Depression (CES-D) scale = 16) was assessed annually at four follow-up visits. Marginal structural models that account for time-dependent confounding and attrition evaluated the association between each time-varying disease severity measure and depression onset. Results. Each disease severity measure exhibited a non-linear relationship concerning the probability of depression onset, with the higher quintiles generally being associated with a larger risk. The highest quintile (relative to the lowest) of joint space width and gait speed were both significantly associated with depression onset. By contrast, none of the higher pain quintiles compared with the lowest were significantly associated with the onset of depression. Conclusion. Faster disease progression as measured by either worsening structural severity or decreasing physical performance corresponds to an increased risk of depression among individuals with radiographic knee OA.Funding Information
- Rheumatology Research Foundation’s Scientist Development Award and grants
- National Institute on Aging (K01 AG064041)
- Rheumatology Research Foundation and National Institute on Aging
- NIA (K01 AG064041)
- NIA (R01 AG048069)
- VA Rehabilitation Research and Development Service (I01 RX002790, I01 RX001461, I21 RX002870)
- NIA (P30 AG028747)
- National Institute on Diabetes and Digestive and Kidney Disease (P30 DK072488)
- National Institutes of Health (R01 AR075356)
- National Institute on Mental Health
- NIMH (R25 MH104660)
- NIMH (R01 MH115487, P50 MH115842)
This publication has 46 references indexed in Scilit:
- Test-retest reliability and sensitivity of the 20-meter walk test among patients with knee osteoarthritisBMC Musculoskeletal Disorders, 2013
- Reciprocal Relationship Between Pain and Depression: A 12-Month Longitudinal Analysis in Primary CareThe Journal of Pain, 2011
- OARSI-FDA initiative: defining the disease state of osteoarthritisOsteoarthritis and Cartilage, 2011
- Comparison of radiographic joint space width with magnetic resonance imaging cartilage morphometry: Analysis of longitudinal data from the osteoarthritis initiativeArthritis Care & Research, 2010
- The discordance between clinical and radiographic knee osteoarthritis: A systematic search and summary of the literatureBMC Musculoskeletal Disorders, 2008
- Constructing Inverse Probability Weights for Marginal Structural ModelsAmerican Journal of Epidemiology, 2008
- Estimates of the prevalence of arthritis and other rheumatic conditions in the United States: Part IIArthritis & Rheumatism, 2007
- Validation of a combined comorbidity indexJournal of Clinical Epidemiology, 1994
- The CES-D ScaleApplied Psychological Measurement, 1977
- Radiological Assessment of Osteo-ArthrosisAnnals Of The Rheumatic Diseases, 1957