Hypothalamic glucose-sensing mechanisms
- 5 February 2021
- journal article
- review article
- Published by Springer Science and Business Media LLC in Diabetologia
- Vol. 64 (5), 985-993
- https://doi.org/10.1007/s00125-021-05395-6
Abstract
Chronic metabolic diseases, including diabetes and obesity, have become a major global health threat of the twenty-first century. Maintaining glucose homeostasis is essential for survival in mammals. Complex and highly coordinated interactions between glucose-sensing mechanisms and multiple effector systems are essential for controlling glucose levels in the blood. The central nervous system (CNS) plays a crucial role in regulating glucose homeostasis. Growing evidence indicates that disruption of glucose sensing in selective CNS areas, such as the hypothalamus, is closely interlinked with the pathogenesis of obesity and type 2 diabetes mellitus. However, the underlying intracellular mechanisms of glucose sensing in the hypothalamus remain elusive. Here, we review the current literature on hypothalamic glucose-sensing mechanisms and discuss the impact of alterations of these mechanisms on the pathogenesis of diabetes. Graphical abstractKeywords
Funding Information
- NIH (DK120321)
This publication has 58 references indexed in Scilit:
- Insulin Resistance and Type 2 DiabetesDiabetes, 2012
- Obesity is associated with hypothalamic injury in rodents and humansJCI Insight, 2012
- Glucose Sensing Neurons in the Ventromedial HypothalamusSensors, 2010
- Brain Insulin Action Regulates Hypothalamic Glucose Sensing and the Counterregulatory Response to HypoglycemiaDiabetes, 2010
- AMP-activated protein kinase and nitric oxide regulate the glucose sensitivity of ventromedial hypothalamic glucose-inhibited neuronsAmerican Journal of Physiology-Cell Physiology, 2009
- Fasting enhances the response of arcuate neuropeptide Y-glucose-inhibited neurons to decreased extracellular glucoseAmerican Journal of Physiology-Cell Physiology, 2009
- Connexin channel permeability to cytoplasmic moleculesProgress in Biophysics and Molecular Biology, 2007
- Synaptic Glutamate Release by Ventromedial Hypothalamic Neurons Is Part of the Neurocircuitry that Prevents HypoglycemiaCell Metabolism, 2007
- Differential changes in brain glucose metabolism during hypoglycaemia accompany loss of hypoglycaemia awareness in men with type 1 diabetes mellitus. An [11C]-3-O-methyl-d-glucose PET studyDiabetologia, 2005
- Let There Be (NADH) LightScience, 2004